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The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

Authors
 Eunjoo Kim  ;  Dong-Ho Song  ;  Nam-Wook Kim  ;  In-Jung Sohn  ;  Keun-Ah Cheon 
Citation
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.15(3) : 222-228, 2017 
Journal Title
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE 
ISSN
 1738-1088 
Issue Date
2017
Keywords
Attention deficit disorder with hyperactivity ; Continuous performance test ; Omission errors ; SNAP-25
Abstract
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
Files in This Item:
T201703029.pdf Download
DOI
10.9758/cpn.2017.15.3.222
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun Joo(김은주) ORCID logo https://orcid.org/0000-0003-3061-2051
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160664
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