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The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

DC Field Value Language
dc.contributor.author김은주-
dc.contributor.author송동호-
dc.contributor.author천근아-
dc.date.accessioned2018-07-20T07:55:07Z-
dc.date.available2018-07-20T07:55:07Z-
dc.date.issued2017-
dc.identifier.issn1738-1088-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160664-
dc.description.abstractObjective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherKorean College of Neuropsychopharmacology-
dc.relation.isPartOfCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorEunjoo Kim-
dc.contributor.googleauthorDong-Ho Song-
dc.contributor.googleauthorNam-Wook Kim-
dc.contributor.googleauthorIn-Jung Sohn-
dc.contributor.googleauthorKeun-Ah Cheon-
dc.identifier.doi10.9758/cpn.2017.15.3.222-
dc.contributor.localIdA00820-
dc.contributor.localIdA02018-
dc.contributor.localIdA04027-
dc.relation.journalcodeJ00609-
dc.identifier.eissn2093-4327-
dc.identifier.pmid28783930-
dc.subject.keywordAttention deficit disorder with hyperactivity-
dc.subject.keywordContinuous performance test-
dc.subject.keywordOmission errors-
dc.subject.keywordSNAP-25-
dc.contributor.alternativeNameKim, Eun Joo-
dc.contributor.alternativeNameSong, Dong Ho-
dc.contributor.alternativeNameCheon, Keun Ah-
dc.contributor.affiliatedAuthorKim, Eun Joo-
dc.contributor.affiliatedAuthorSong, Dong Ho-
dc.contributor.affiliatedAuthorCheon, Keun Ah-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPage222-
dc.citation.endPage228-
dc.identifier.bibliographicCitationCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.15(3) : 222-228, 2017-
dc.identifier.rimsid41836-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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