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Surface Topographic Effect on Mesenchymal Stem Cells in Tissue Engineering

Authors
 Yun, Young-Shik  ;  Kang, Eun-Hye  ;  Yun, In Sik  ;  Kim, Yong Oock  ;  Yeo, Jong-Souk 
Citation
 Journal of International Society for Simulation Surgery, Vol.4(1) : 1-8, 2017 
Journal Title
 Journal of International Society for Simulation Surgery 
ISSN
 2383-5389 
Issue Date
2017
Keywords
Tissue engineering ; Regenerative medicine ; Mesenchymal stem cells ; Topographic effect
Abstract
In the field of tissue engineering, researches have been actively conducted to regulate stem cell fate by understanding the interaction between cell and materials. This approach is expected as a promising therapeutic method in the future medicine by utilizing differentiation of stem cells into desired cells or tissues using biomaterial. For this regenerative medicine, there exist lots of attempts to construct optimized structures of various shapes and sizes that can regulate the stem cell fate. In this review, we will empathize the topographic effect as stem cell niche on the mesenchymal stem cell (MSC) response (cell attachment, proliferation, and differentiation) according to the shape and size of the structure of the substrates, and comprehensively analyze the importance and the effect of shape and size of the surface topography.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
김용욱(Kim, Yong Oock) ORCID logo https://orcid.org/0000-0002-3756-4809
윤인식(Yun, In Sik) ORCID logo https://orcid.org/0000-0003-1103-7047
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160648
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