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Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering

Authors
 Mounica Yanamandala  ;  Wuqiang Zhu  ;  Daniel J. Garry  ;  Timothy J. Kamp  ;  Joshua M. Hare  ;  Ho-wook Jun  ;  Young-sup Yoon  ;  Nenad Bursac  ;  Sumanth D. Prabhu  ;  Gerald W. Dorn II  ;  Roberto Bolli  ;  Richard N. Kitsis  ;  Jianyi Zhang 
Citation
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.70(6) : 766-775, 2017 
Journal Title
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 
ISSN
 0735-1097 
Issue Date
2017
MeSH
Cell- and Tissue-Based Therapy/methods* ; Heart Diseases/therapy* ; Humans ; Tissue Engineering/methods*
Keywords
biocompatible materials ; heart failure ; myocardial infarction ; myocardium ; stem cells
Abstract
Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts. Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.
Files in This Item:
T201702765.pdf Download
DOI
10.1016/j.jacc.2017.06.012
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sup(윤영섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160617
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