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Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering

DC FieldValueLanguage
dc.contributor.author윤영섭-
dc.date.accessioned2018-07-20T07:52:27Z-
dc.date.available2018-07-20T07:52:27Z-
dc.date.issued2017-
dc.identifier.issn0735-1097-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160617-
dc.description.abstractTransplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts. Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier Biomedical-
dc.relation.isPartOfJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell- and Tissue-Based Therapy/methods*-
dc.subject.MESHHeart Diseases/therapy*-
dc.subject.MESHHumans-
dc.subject.MESHTissue Engineering/methods*-
dc.titleOvercoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorMounica Yanamandala-
dc.contributor.googleauthorWuqiang Zhu-
dc.contributor.googleauthorDaniel J. Garry-
dc.contributor.googleauthorTimothy J. Kamp-
dc.contributor.googleauthorJoshua M. Hare-
dc.contributor.googleauthorHo-wook Jun-
dc.contributor.googleauthorYoung-sup Yoon-
dc.contributor.googleauthorNenad Bursac-
dc.contributor.googleauthorSumanth D. Prabhu-
dc.contributor.googleauthorGerald W. Dorn II-
dc.contributor.googleauthorRoberto Bolli-
dc.contributor.googleauthorRichard N. Kitsis-
dc.contributor.googleauthorJianyi Zhang-
dc.identifier.doi10.1016/j.jacc.2017.06.012-
dc.contributor.localIdA02579-
dc.relation.journalcodeJ01770-
dc.identifier.eissn1558-3597-
dc.identifier.pmid28774384-
dc.subject.keywordbiocompatible materials-
dc.subject.keywordheart failure-
dc.subject.keywordmyocardial infarction-
dc.subject.keywordmyocardium-
dc.subject.keywordstem cells-
dc.contributor.alternativeNameYoon, Young Sup-
dc.contributor.affiliatedAuthorYoon, Young Sup-
dc.citation.volume70-
dc.citation.number6-
dc.citation.startPage766-
dc.citation.endPage775-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.70(6) : 766-775, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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