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Location of residual viable tumor cells after neoadjuvant chemotherapy: A new concept with high prognostic performance in osteosarcoma

DC FieldValueLanguage
dc.contributor.author공영호-
dc.contributor.author김승현-
dc.contributor.author문성환-
dc.contributor.author서진석-
dc.contributor.author신규호-
dc.contributor.author양우익-
dc.date.accessioned2018-07-20T07:51:22Z-
dc.date.available2018-07-20T07:51:22Z-
dc.date.issued2017-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160598-
dc.description.abstractBACKGROUND AND OBJECTIVES: The purpose of this study was to establish a new concept for evaluating responses to neoadjuvant chemotherapy in osteosarcoma. METHODS: A total of 56 high-grade extremity osteosarcoma patients were retrospectively reviewed. A new conceptual method was derived from locations of residual viable tumor cells (LRVTC) after chemotherapy, whether extracompartmental or intracompartmental, rather than quantitative measurements of necrosis rates of tumor cells. RESULTS: LRVTC after chemotherapy was independently associated with overall survival ([OS]hazard ratio [HR] = 6.502, P = 0.008) after adjustment for Huvos grade (HR = 3.694, P = 0.045), alkaline phosphatase ([ALP] HR = 2.140, P = 0.226), size (HR = 0.318, P = 0.133), joint extension (HR = 2.309, P = 0.162), and metastasis at diagnosis (HR = 8.228, P = 0.009). LRVTC was also independently associated with metastasis (HR = 5.096, P = 0.002) after adjustment for Huvos grade (HR = 2.261, P = 0.101), ALP (HR = 2.558, P = 0.053), size (HR = 1.280, P = 0.641), and joint extension (HR = 1.800, P = 0.254). AUC values of LRVTC for OS and metastasis were superior to those of Huvos grade: AUCs for OS (LRVTC: 0.757, Confidence Interval [CI] = 0.618 to 0.865 vs Huvos grade: 0.590, [CI] = 0.445 to 0.725; AUC = 0.167, P = 0.086) and metastasis (LRVTC: 0.769, CI = 0.631 to 0.874 vs Huvos grade: 0.606, [CI] = 0.461 to 0.739; AUC = 0.163, P = 0.046). CONCLUSIONS: LRVTC after chemotherapy may be useful as a new method with high performance for evaluating chemo-responses in osteosarcoma.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLocation of residual viable tumor cells after neoadjuvant chemotherapy: A new concept with high prognostic performance in osteosarcoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Orthopedic Surgery-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorKyoo‐Ho Shin-
dc.contributor.googleauthorSeong‐Hwan Moon-
dc.contributor.googleauthorYoungho Kong-
dc.contributor.googleauthorJin‐Suck Suh-
dc.contributor.googleauthorWoo‐Ick Yang-
dc.identifier.doi10.1002/jso.24571-
dc.contributor.localIdA05297-
dc.contributor.localIdA00662-
dc.contributor.localIdA01365-
dc.contributor.localIdA01916-
dc.contributor.localIdA02086-
dc.contributor.localIdA02300-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid28403564-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jso.24571-
dc.subject.keywordlocations of residual viable tumor cells (LRVTC)-
dc.subject.keywordosteosarcoma-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKong, Youngho-
dc.contributor.alternativeNameKim, Seung Hyun-
dc.contributor.alternativeNameMoon, Seong Hwan-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.affiliatedAuthorKong, Youngho-
dc.contributor.affiliatedAuthorKim, Seung Hyun-
dc.contributor.affiliatedAuthorMoon, Seong Hwan-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.citation.volume115-
dc.citation.number6-
dc.citation.startPage752-
dc.citation.endPage759-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.115(6) : 752-759, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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