Cited 4 times in
Location of residual viable tumor cells after neoadjuvant chemotherapy: A new concept with high prognostic performance in osteosarcoma
DC Field | Value | Language |
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dc.contributor.author | 공영호 | - |
dc.contributor.author | 김승현 | - |
dc.contributor.author | 문성환 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 신규호 | - |
dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2018-07-20T07:51:22Z | - |
dc.date.available | 2018-07-20T07:51:22Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160598 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: The purpose of this study was to establish a new concept for evaluating responses to neoadjuvant chemotherapy in osteosarcoma. METHODS: A total of 56 high-grade extremity osteosarcoma patients were retrospectively reviewed. A new conceptual method was derived from locations of residual viable tumor cells (LRVTC) after chemotherapy, whether extracompartmental or intracompartmental, rather than quantitative measurements of necrosis rates of tumor cells. RESULTS: LRVTC after chemotherapy was independently associated with overall survival ([OS]hazard ratio [HR] = 6.502, P = 0.008) after adjustment for Huvos grade (HR = 3.694, P = 0.045), alkaline phosphatase ([ALP] HR = 2.140, P = 0.226), size (HR = 0.318, P = 0.133), joint extension (HR = 2.309, P = 0.162), and metastasis at diagnosis (HR = 8.228, P = 0.009). LRVTC was also independently associated with metastasis (HR = 5.096, P = 0.002) after adjustment for Huvos grade (HR = 2.261, P = 0.101), ALP (HR = 2.558, P = 0.053), size (HR = 1.280, P = 0.641), and joint extension (HR = 1.800, P = 0.254). AUC values of LRVTC for OS and metastasis were superior to those of Huvos grade: AUCs for OS (LRVTC: 0.757, Confidence Interval [CI] = 0.618 to 0.865 vs Huvos grade: 0.590, [CI] = 0.445 to 0.725; AUC = 0.167, P = 0.086) and metastasis (LRVTC: 0.769, CI = 0.631 to 0.874 vs Huvos grade: 0.606, [CI] = 0.461 to 0.739; AUC = 0.163, P = 0.046). CONCLUSIONS: LRVTC after chemotherapy may be useful as a new method with high performance for evaluating chemo-responses in osteosarcoma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Location of residual viable tumor cells after neoadjuvant chemotherapy: A new concept with high prognostic performance in osteosarcoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Orthopedic Surgery | - |
dc.contributor.googleauthor | Seung Hyun Kim | - |
dc.contributor.googleauthor | Kyoo‐Ho Shin | - |
dc.contributor.googleauthor | Seong‐Hwan Moon | - |
dc.contributor.googleauthor | Youngho Kong | - |
dc.contributor.googleauthor | Jin‐Suck Suh | - |
dc.contributor.googleauthor | Woo‐Ick Yang | - |
dc.identifier.doi | 10.1002/jso.24571 | - |
dc.contributor.localId | A05297 | - |
dc.contributor.localId | A00662 | - |
dc.contributor.localId | A01365 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02086 | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 28403564 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.24571 | - |
dc.subject.keyword | locations of residual viable tumor cells (LRVTC) | - |
dc.subject.keyword | osteosarcoma | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kong, Youngho | - |
dc.contributor.alternativeName | Kim, Seung Hyun | - |
dc.contributor.alternativeName | Moon, Seong Hwan | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Shin, Kyoo Ho | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Kong, Youngho | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Moon, Seong Hwan | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Shin, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.citation.volume | 115 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 752 | - |
dc.citation.endPage | 759 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.115(6) : 752-759, 2017 | - |
dc.identifier.rimsid | 40008 | - |
dc.type.rims | ART | - |
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