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Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea

Authors
 Eun Hye Lee  ;  Jung Mo Lee  ;  Young Ae Kang  ;  Ah Young Leem  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Song Yee Kim 
Citation
 Lung, Vol.195(2) : 209-215, 2017 
Journal Title
 Lung 
ISSN
 0341-2040 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Colony Count, Microbial ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis/isolation & purification ; Prevalence ; Republic of Korea/epidemiology ; Sex Factors ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/microbiology
Keywords
Diabetes mellitus ; Mycobacterium tuberculosis ; Sputum culture conversion ; Treatment outcomes
Abstract
OBJECTIVE: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. SETTING AND DESIGN: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V. RESULTS: Diabetes prevalence was 24.2% (252/1044) among patients with PTB and 11.6% (1700/14,655) among controls. Diabetes [odds ratios (OR) 2.56, 95% confidence interval (CI) 1.56-4.21, P < 0.001], male sex (OR 1.93, 95% CI 1.08-3.44, P = 0.027), and cavitary disease (OR 2.08, 95% CI 1.29-3.35, P = 0.003) were significant risk factors for 2-month culture positivity. Diabetes was the only factor associated with unsuccessful treatment outcomes (OR 1.67, 95% CI 1.03-2.70, P = 0.039). CONCLUSION: The prevalence of diabetes was markedly higher in patients with PTB than in a sample of the general South Korean population. Diabetes may delay sputum conversion and adversely affect treatment outcomes; detection and management of diabetes in patients with PTB is crucial.
Full Text
https://link.springer.com/article/10.1007%2Fs00408-017-9978-4
DOI
10.1007/s00408-017-9978-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김은영(Kim, Eun Young) ORCID logo https://orcid.org/0000-0002-3281-5744
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
이은혜(Lee, Eun Hye) ORCID logo https://orcid.org/0000-0003-2570-3442
이정모(Lee, Jung Mo)
임아영(Leem, Ah Young) ORCID logo https://orcid.org/0000-0001-5165-3704
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정지예(Jung, Ji Ye) ORCID logo https://orcid.org/0000-0003-1589-4142
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160576
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