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Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin

Authors
 Soomin Kim  ;  Ji Eun Jang  ;  Jihee Kim  ;  Young In Lee  ;  Dong Won Lee  ;  Seung Yong Song  ;  Ju Hee Lee 
Citation
 FOOD AND CHEMICAL TOXICOLOGY, Vol.106(Pt A) : 367-375, 2017 
Journal Title
 FOOD AND CHEMICAL TOXICOLOGY 
ISSN
 0278-6915 
Issue Date
2017
MeSH
Adult ; Anti-Inflammatory Agents/analysis ; Anti-Inflammatory Agents/pharmacology* ; Coconut Oil ; Cocos/chemistry* ; Collagen/metabolism ; Humans ; Middle Aged ; Plant Extracts/analysis ; Plant Extracts/pharmacology* ; Plant Oils/analysis ; Plant Oils/pharmacology* ; Polyphenols/analysis ; Polyphenols/pharmacology ; Skin/drug effects* ; Skin/metabolism ; Skin/radiation effects ; Ultraviolet Rays
Keywords
Coconut ; Cultured coconut extract ; Human skin ; Tissue regeneration ; Virgin coconut oil
Abstract
Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.
Full Text
https://www.sciencedirect.com/science/article/pii/S027869151730296X
DOI
10.1016/j.fct.2017.05.060
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Song, Seung Yong(송승용) ORCID logo https://orcid.org/0000-0002-3145-7463
Lee, Dong Won(이동원) ORCID logo https://orcid.org/0000-0003-0046-3139
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160575
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