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Altered functional connectivity in default mode network in Internet gaming disorder: Influence of childhood ADHD

Authors
 Deokjong Lee  ;  Junghan Lee  ;  Jung Eun Lee  ;  Young-Chul Jung 
Citation
 PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, Vol.75 : 135-141, 2017 
Journal Title
 PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 
ISSN
 0278-5846 
Issue Date
2017
MeSH
Adult ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity/complications ; Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Attention Deficit Disorder with Hyperactivity/pathology* ; Brain/diagnostic imaging ; Brain/physiopathology* ; Brain Mapping ; Case-Control Studies ; Gambling/complications ; Gambling/diagnostic imaging ; Gambling/pathology* ; Humans ; Image Processing, Computer-Assisted ; Internet* ; Magnetic Resonance Imaging ; Male ; Models, Neurological* ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiology* ; Oxygen/blood ; Psychiatric Status Rating Scales ; Rest ; Statistics as Topic ; Young Adult
Keywords
ADHD ; Default mode network ; Internet gaming disorder ; Resting-state functional connectivity ; fMRI
Abstract
OBJECTIVE: Internet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD. METHODS: Resting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls. Posterior cingulate cortex (PCC)-seeded connectivity was evaluated to assess abnormalities in default mode network (DMN) connectivity, which is associated with deficits in executive control. RESULTS: IGD subjects without childhood ADHD showed expanded functional connectivity (FC) between DMN-related regions (PCC, medial prefrontal cortex, thalamus) compared with controls. These subjects also exhibited expanded FC between the PCC and brain regions implicated in salience processing (anterior insula, orbitofrontal cortex) compared with IGD subjects with childhood ADHD. IGD subjects with childhood ADHD showed expanded FC between the PCC and cerebellum (crus II), a region involved in executive control. The strength of connectivity between the PCC and cerebellum (crus II) was positively correlated with self-reporting scales reflecting impulsiveness. CONCLUSION: Individuals with IGD showed altered PCC-based FC, the characteristics of which might be dependent upon history of childhood ADHD. Our findings suggest that altered neural networks for executive control in ADHD would be a predisposition for developing IGD.
Full Text
https://www.sciencedirect.com/science/article/pii/S0278584616301452
DOI
10.1016/j.pnpbp.2017.02.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Deokjong(이덕종) ORCID logo https://orcid.org/0000-0002-5425-4677
Lee, Jung Eun(이정은)
Lee, Junghan(이정한)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160515
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