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A lexicon for hepatocellular carcinoma surveillance ultrasonography: benign versus malignant lesions

DC Field Value Language
dc.contributor.author김명진-
dc.contributor.author박미숙-
dc.contributor.author서니은-
dc.contributor.author안찬식-
dc.contributor.author이진영-
dc.date.accessioned2018-07-20T07:43:44Z-
dc.date.available2018-07-20T07:43:44Z-
dc.date.issued2017-
dc.identifier.issn2287-2728-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160468-
dc.description.abstractBACKGROUND/AIMS: To suggest a lexicon for liver ultrasonography and to identify radiologic features indicative of benign or malignant lesions on surveillance ultrasonography. METHODS: This retrospective study included 188 nodules (benign, 101; malignant, 87) from 175 at-risk patients identified during surveillance ultrasonography for hepatocellular carcinoma. We created a lexicon for liver ultrasonography by reviewing relevant literature regarding the ultrasonographic features of hepatic lesions. Using this lexicon, two abdominal radiologists determined the presence or absence of each ultrasonographic feature for the included hepatic lesions. Independent factors associated with malignancy and interobserver agreement were determined by logistic regression analysis and kappa statistics, respectively. RESULTS: Larger tumor size (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.06-1.183; P<0.001), multinodular confluent morphology (OR, 7.712; 95% CI, 1.053-56.465; P=0.044), thick hypoechoic rim (OR, 5.878; 95% CI, 2.681-12.888; P<0.001), and posterior acoustic enhancement (OR, 3.077; 95% CI, 1.237-7.655; P=0.016) were independently associated with malignant lesions. In a subgroup analysis of lesions <2 cm, none of the ultrasonographic features were significantly associated with malignancy or benignity. Interobserver agreement for morphology was fair (κ=0.36), while those for rim (κ=0.427), echogenicity (κ=0.549), and posterior acoustic enhancement (κ=0.543) were moderate. CONCLUSIONS: For hepatic lesions larger than 2 cm, some ultrasonography (US) features might be suggestive of malignancy. We propose a lexicon that may be useful for surveillance US.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Association for the Study of the Liver-
dc.relation.isPartOfCLINICAL AND MOLECULAR HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/complications-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging*-
dc.subject.MESHContrast Media/chemistry-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B/complications-
dc.subject.MESHHumans-
dc.subject.MESHLiver/diagnostic imaging-
dc.subject.MESHLiver Neoplasms/complications-
dc.subject.MESHLiver Neoplasms/diagnostic imaging*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHUltrasonography-
dc.subject.MESHalpha-Fetoproteins/analysis-
dc.titleA lexicon for hepatocellular carcinoma surveillance ultrasonography: benign versus malignant lesions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorChansik An-
dc.contributor.googleauthorGulbahor Rakhmonova-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorNieun Seo-
dc.contributor.googleauthorJin Young Lee-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorMi-Suk Park-
dc.identifier.doi10.3350/cmh.2016.0041-
dc.contributor.localIdA00426-
dc.contributor.localIdA01463-
dc.contributor.localIdA01874-
dc.contributor.localIdA02268-
dc.contributor.localIdA05387-
dc.relation.journalcodeJ00557-
dc.identifier.eissn2287-285X-
dc.identifier.pmid28349678-
dc.subject.keywordCarcinoma, Hepatocellular-
dc.subject.keywordSurveillance-
dc.subject.keywordUltrasonography-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNameSeo, Nieun-
dc.contributor.alternativeNameAn, Chan Sik-
dc.contributor.alternativeNameLee, Jin Young-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorSeo, Nieun-
dc.contributor.affiliatedAuthorAn, Chan Sik-
dc.contributor.affiliatedAuthorLee, Jin Young-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage57-
dc.citation.endPage65-
dc.identifier.bibliographicCitationCLINICAL AND MOLECULAR HEPATOLOGY, Vol.23(1) : 57-65, 2017-
dc.identifier.rimsid42304-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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