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Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats

DC Field Value Language
dc.contributor.author김종열-
dc.contributor.author이종은-
dc.contributor.author박주현-
dc.date.accessioned2018-07-20T07:43:16Z-
dc.date.available2018-07-20T07:43:16Z-
dc.date.issued2017-
dc.identifier.issn1549-9634-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160459-
dc.description.abstractIntracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBiocompatible Materials-
dc.subject.MESHCerebral Hemorrhage/drug therapy*-
dc.subject.MESHCollagenases-
dc.subject.MESHDisease Models, Animal*-
dc.subject.MESHHematoma/chemically induced-
dc.subject.MESHHematoma/pathology-
dc.subject.MESHHematoma/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMicroglia-
dc.subject.MESHNeuroprotective Agents/therapeutic use*-
dc.subject.MESHPeptide Fragments/therapeutic use*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHTemperature-
dc.subject.MESHThermodynamics-
dc.subject.MESHTropoelastin/administration & dosage*-
dc.subject.MESHTropoelastin/chemistry-
dc.titleThermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorJoohyun Park-
dc.contributor.googleauthorJong Youl Kim-
dc.contributor.googleauthorSeong-Kyoon Choi-
dc.contributor.googleauthorJae Young Kim-
dc.contributor.googleauthorJae Hwan Kim-
dc.contributor.googleauthorWon Bae Jeon-
dc.contributor.googleauthorJong Eun Lee-
dc.identifier.doi10.1016/j.nano.2017.04.001-
dc.contributor.localIdA00923-
dc.contributor.localIdA03146-
dc.relation.journalcodeJ02934-
dc.identifier.eissn1549-9642-
dc.identifier.pmid28412143-
dc.subject.keywordElastin-like polypeptide-
dc.subject.keywordIntracerebral hemorrhage-
dc.subject.keywordNanomaterial-
dc.subject.keywordRGD-containing elastin-like polypeptide-
dc.contributor.alternativeNameKim, Jong Youl-
dc.contributor.alternativeNameLee, Jong Eun-
dc.contributor.affiliatedAuthorKim, Jong Youl-
dc.contributor.affiliatedAuthorLee, Jong Eun-
dc.citation.volume13-
dc.citation.number6-
dc.citation.startPage1853-
dc.citation.endPage1862-
dc.identifier.bibliographicCitationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol.13(6) : 1853-1862, 2017-
dc.identifier.rimsid42295-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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