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Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes.

 Eugene Han  ;  Gyuri Kim  ;  Ji-Yeon Lee  ;  Yong-ho Lee  ;  Beom Seok Kim  ;  Byung-Wan Lee  ;  Bong-Soo Cha  ;  Eun Seok Kang 
 Endocrinology and Metabolism (대한내분비학회지), Vol.32(2) : 274-280, 2017 
Journal Title
 Endocrinology and Metabolism (대한내분비학회지) 
Issue Date
Atorvastatin calcium ; Diabetes mellitus ; Renal insufficiency, chronic ; Rosuvastatin calcium
BACKGROUND: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. METHODS: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. We included patients treated with moderate-intensity dose statin treatment (atorvastatin 10 to 20 mg/day or rosuvastatin 5 to 10 mg/day). The primary outcome was a change in estimated glomerular filtration rate (eGFR) during the 12-month statin treatment, and rapid renal decline was defined as a >3% reduction in eGFR in a 1-year period. RESULTS: In both statin treatment groups, patients showed improved serum lipid levels and significantly reduced eGFRs (from 80.3 to 78.8 mL/min/1.73 m² for atorvastatin [P=0.012], from 79.1 to 76.1 mL/min/1.73 m² for rosuvastatin [P=0.001]). A more rapid eGFR decline was observed in the rosuvastatin group than in the atorvastatin group (48.7% vs. 38.6%, P=0.029). Multiple logistic regression analyses demonstrated more rapid renal function loss in the rosuvastatin group than in the atorvastatin group after adjustment for other confounding factors (odds ratio, 1.60; 95% confidence interval, 1.06 to 2.42). CONCLUSION: These results suggest that a moderate-intensity dose of atorvastatin has fewer detrimental effects on renal function than that of rosuvastatin.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김규리(Kim, Gyuri)
김범석(Kim, Beom Seok) ORCID logo https://orcid.org/0000-0002-5732-2583
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
이지연(Lee, Ji Yeon)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
한유진(Han, Eu Gene)
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