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Cited 2 times in

Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes.

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김규리-
dc.contributor.author김범석-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author이지연-
dc.contributor.author차봉수-
dc.contributor.author한유진-
dc.date.accessioned2018-07-20T07:39:26Z-
dc.date.available2018-07-20T07:39:26Z-
dc.date.issued2017-
dc.identifier.issn2093-596X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160389-
dc.description.abstractBACKGROUND: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. METHODS: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. We included patients treated with moderate-intensity dose statin treatment (atorvastatin 10 to 20 mg/day or rosuvastatin 5 to 10 mg/day). The primary outcome was a change in estimated glomerular filtration rate (eGFR) during the 12-month statin treatment, and rapid renal decline was defined as a >3% reduction in eGFR in a 1-year period. RESULTS: In both statin treatment groups, patients showed improved serum lipid levels and significantly reduced eGFRs (from 80.3 to 78.8 mL/min/1.73 m² for atorvastatin [P=0.012], from 79.1 to 76.1 mL/min/1.73 m² for rosuvastatin [P=0.001]). A more rapid eGFR decline was observed in the rosuvastatin group than in the atorvastatin group (48.7% vs. 38.6%, P=0.029). Multiple logistic regression analyses demonstrated more rapid renal function loss in the rosuvastatin group than in the atorvastatin group after adjustment for other confounding factors (odds ratio, 1.60; 95% confidence interval, 1.06 to 2.42). CONCLUSION: These results suggest that a moderate-intensity dose of atorvastatin has fewer detrimental effects on renal function than that of rosuvastatin.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Endocrine Society-
dc.relation.isPartOfEndocrinology and Metabolism (대한내분비학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorEugene Han-
dc.contributor.googleauthorGyuri Kim-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorEun Seok Kang-
dc.identifier.doi10.3803/EnM.2017.32.2.274-
dc.contributor.localIdA00068-
dc.contributor.localIdA00322-
dc.contributor.localIdA00488-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03197-
dc.contributor.localIdA03996-
dc.contributor.localIdA04311-
dc.relation.journalcodeJ00773-
dc.identifier.eissn2093-5978-
dc.identifier.pmid28685516-
dc.subject.keywordAtorvastatin calcium-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordRenal insufficiency, chronic-
dc.subject.keywordRosuvastatin calcium-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Gyuri-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHan, Eu Gene-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Gyuri-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHan, Eu Gene-
dc.citation.volume32-
dc.citation.number2-
dc.citation.startPage274-
dc.citation.endPage280-
dc.identifier.bibliographicCitationEndocrinology and Metabolism (대한내분비학회지), Vol.32(2) : 274-280, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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