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Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children

 Soyoung Park  ;  Eun Joo Lee  ;  Soyong Eom  ;  Hoon-Chul Kang  ;  Joon Soo Lee  ;  Heung Dong Kim 
 Journal of Epilepsy Research, Vol.7(1) : 45-49, 2017 
Journal Title
 Journal of Epilepsy Research 
Issue Date
Children ; Epilepsy ; Ketogenic diet ; Tuberous sclerosis complex
BACKGROUND AND PURPOSE: In the present study, we reviewed the outcome of ketogenic diet (KD) use for the management of epilepsy in children with tuberous sclerosis complex (TSC). METHODS: A total of 12 children with intractable epilepsy associated with TSC who were treated with KD at our hospital between March 1, 2008 and February 28, 2015 were retrospectively enrolled. RESULTS: The mean age at the time of KD initiation was 73.1 ± 38.0 months. Patients were medically refractory to a mean of 4.8 ± 1.7 antiepileptic drugs. Nine patients (75.0%) had a history of infantile spasms. At 3 months after KD initiation, 10 patients (83.3%) had > 50% seizure reduction. Moreover, 7 patients (58.3%) exhibited qualitative improvements in cognition and behavior after KD initiation, as reported by caregivers/parents. The mean duration of dietary therapy was 14.8 ± 12.8 months. Half of the patients in this study eventually underwent epilepsy surgery due to persistent seizures or seizure relapse. CONCLUSION: KD is an important non-pharmacological treatment option for patients with intractable epilepsy associated with TSC. KD may improve cognition and behavior in addition to reducing seizure frequency.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
강훈철(Kang, Hoon Chul) ORCID logo https://orcid.org/0000-0002-3659-8847
김흥동(Kim, Heung Dong) ORCID logo https://orcid.org/0000-0002-8031-7336
이은주(Lee, Eunjoo)
이준수(Lee, Joon Soo) ORCID logo https://orcid.org/0000-0001-9036-9343
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