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Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김흥동-
dc.contributor.author이은주-
dc.contributor.author이준수-
dc.date.accessioned2018-07-20T07:34:43Z-
dc.date.available2018-07-20T07:34:43Z-
dc.date.issued2017-
dc.identifier.issn2233-6249-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160305-
dc.description.abstractBACKGROUND AND PURPOSE: In the present study, we reviewed the outcome of ketogenic diet (KD) use for the management of epilepsy in children with tuberous sclerosis complex (TSC). METHODS: A total of 12 children with intractable epilepsy associated with TSC who were treated with KD at our hospital between March 1, 2008 and February 28, 2015 were retrospectively enrolled. RESULTS: The mean age at the time of KD initiation was 73.1 ± 38.0 months. Patients were medically refractory to a mean of 4.8 ± 1.7 antiepileptic drugs. Nine patients (75.0%) had a history of infantile spasms. At 3 months after KD initiation, 10 patients (83.3%) had > 50% seizure reduction. Moreover, 7 patients (58.3%) exhibited qualitative improvements in cognition and behavior after KD initiation, as reported by caregivers/parents. The mean duration of dietary therapy was 14.8 ± 12.8 months. Half of the patients in this study eventually underwent epilepsy surgery due to persistent seizures or seizure relapse. CONCLUSION: KD is an important non-pharmacological treatment option for patients with intractable epilepsy associated with TSC. KD may improve cognition and behavior in addition to reducing seizure frequency.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Epilepsy Society-
dc.relation.isPartOfJournal of Epilepsy Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleKetogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorSoyoung Park-
dc.contributor.googleauthorEun Joo Lee-
dc.contributor.googleauthorSoyong Eom-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorHeung Dong Kim-
dc.identifier.doi10.14581/jer.17008-
dc.contributor.localIdA00102-
dc.contributor.localIdA01208-
dc.contributor.localIdA05008-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ01404-
dc.identifier.eissn2233-6257-
dc.identifier.pmid28775955-
dc.subject.keywordChildren-
dc.subject.keywordEpilepsy-
dc.subject.keywordKetogenic diet-
dc.subject.keywordTuberous sclerosis complex-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameLee, Eunjoo-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorLee, Eunjoo-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage45-
dc.citation.endPage49-
dc.identifier.bibliographicCitationJournal of Epilepsy Research, Vol.7(1) : 45-49, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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