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Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이은주 | - |
dc.contributor.author | 이준수 | - |
dc.date.accessioned | 2018-07-20T07:34:43Z | - |
dc.date.available | 2018-07-20T07:34:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2233-6249 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160305 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: In the present study, we reviewed the outcome of ketogenic diet (KD) use for the management of epilepsy in children with tuberous sclerosis complex (TSC). METHODS: A total of 12 children with intractable epilepsy associated with TSC who were treated with KD at our hospital between March 1, 2008 and February 28, 2015 were retrospectively enrolled. RESULTS: The mean age at the time of KD initiation was 73.1 ± 38.0 months. Patients were medically refractory to a mean of 4.8 ± 1.7 antiepileptic drugs. Nine patients (75.0%) had a history of infantile spasms. At 3 months after KD initiation, 10 patients (83.3%) had > 50% seizure reduction. Moreover, 7 patients (58.3%) exhibited qualitative improvements in cognition and behavior after KD initiation, as reported by caregivers/parents. The mean duration of dietary therapy was 14.8 ± 12.8 months. Half of the patients in this study eventually underwent epilepsy surgery due to persistent seizures or seizure relapse. CONCLUSION: KD is an important non-pharmacological treatment option for patients with intractable epilepsy associated with TSC. KD may improve cognition and behavior in addition to reducing seizure frequency. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Epilepsy Society | - |
dc.relation.isPartOf | Journal of Epilepsy Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Soyoung Park | - |
dc.contributor.googleauthor | Eun Joo Lee | - |
dc.contributor.googleauthor | Soyong Eom | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.identifier.doi | 10.14581/jer.17008 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A05008 | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J01404 | - |
dc.identifier.eissn | 2233-6257 | - |
dc.identifier.pmid | 28775955 | - |
dc.subject.keyword | Children | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Ketogenic diet | - |
dc.subject.keyword | Tuberous sclerosis complex | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.alternativeName | Lee, Eunjoo | - |
dc.contributor.alternativeName | Lee, Joon Soo | - |
dc.contributor.affiliatedAuthor | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Lee, Eunjoo | - |
dc.contributor.affiliatedAuthor | Lee, Joon Soo | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 49 | - |
dc.identifier.bibliographicCitation | Journal of Epilepsy Research, Vol.7(1) : 45-49, 2017 | - |
dc.identifier.rimsid | 40414 | - |
dc.type.rims | ART | - |
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