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Factors Determining Aortic Valve Dysfunction in Korean Subjects With a Bicuspid Aortic Valve

 Soo Youn Lee  ;  Chi Young Shim  ;  Darae Kim  ;  Iksung Cho  ;  Geu-Ru Hong  ;  Jong-Won Ha  ;  Namsik Chung 
 American Journal of Cardiology, Vol.119(12) : 2049-2055, 2017 
Journal Title
 American Journal of Cardiology 
Issue Date
Adult ; Age Factors ; Aged ; Aortic Valve/abnormalities* ; Aortic Valve/diagnostic imaging* ; Aortic Valve/physiopathology ; Aortic Valve Insufficiency/epidemiology ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/physiopathology* ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/physiopathology* ; Echocardiography, Doppler ; Female ; Follow-Up Studies ; Heart Valve Diseases/complications* ; Heart Valve Diseases/diagnosis ; Heart Valve Diseases/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment* ; Risk Factors ; Sex Factors ; Survival Rate/trends
Bicuspid aortic valve (BAV) disease has a male predominance of approximately 3:1 and shows diverse presentations about aortic valve dysfunction. This study aimed to find independent determinants for significant aortic stenosis (AS) or significant aortic regurgitation (AR) in adults with BAV. We retrospectively investigated the medical records of 1,073 subjects (773 men, mean age 55 ± 14 years) who were first diagnosed with BAV disease by transthoracic echocardiography. We excluded 52 subjects with both significant AS and significant AR. Of the remaining 1,021 subjects, 418 (41%) presented with significant AS, 249 (24%) showed significant AR, and the rest of the subjects were grouped into a normal functioning BAV (n = 354, 35%). BAV morphology was classified into the following 4 types according to position and pattern of raphe and cusps: (1) fusion of the right and left coronary cusps (type 1), (2) fusion of the right and noncoronary cusps (type 2), (3) fusion of the left and noncoronary (type 3), and (4) no raphe (type 0). Patients with significant AS were older, more likely to be women than men, and had a higher prevalence of type 0 BAV. Patients with significant AR were younger and were more likely to be men. In multivariate logistic regression analysis, women, older age, and type 0 or type 3 BAV were associated with significant AS. In contrast, men, hypertension, and chronic kidney disease were correlated with significant AR. Significant valve dysfunction in adults with first diagnosed BAV was closely associated with age, gender, and BAV morphology.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김다래(Kim, Da Rae)
심지영(Shim, Chi Young) ORCID logo https://orcid.org/0000-0002-6136-0136
정남식(Chung, Nam Sik)
하종원(Ha, Jong Won) ORCID logo https://orcid.org/0000-0002-8260-2958
홍그루(Hong, Geu Ru) ORCID logo https://orcid.org/0000-0003-4981-3304
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