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Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease

Authors
 Yuri Ahn  ;  Ji-Hye Hwang  ;  Zhenlong Zheng  ;  Dongsik Bang  ;  Do-Young Kim 
Citation
 Scientific Reports, Vol.7(1) : 3018, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
The etiology of Behçet's disease (BD), a chronic, multisystemic autoinflammatory and autoimmune disease, remains unknown; however, researchers have postulated that infectious agents, such as herpes simplex virus, are significant triggering factors of BD. Tripartite motif-containing (TRIM) proteins exhibit antiviral properties, mediating antiviral defense mechanisms. The purpose of this study was to investigate TRIM21 protein expression in the monocytes of BD patients and to identify the role of TRIM21 in immune dysregulation in BD. In this study, the expression of TRIM21 and related molecules, including interferon regulatory factor 8 (IRF8), was analyzed in monocytes from BD patients. Functional analyses using small interfering RNA and co-culture with responder T cells were performed to examine the pathological role of TRIM21 in BD. Peripheral blood monocytes from BD patients showed increased TRIM21 expression and decreased IRF8 expression compared with that in monocytes from healthy controls. TRIM21 was found to decrease IRF8 expression. BD monocytes facilitated Th1 and Th17 differentiation of co-cultured T cells, and knock-down of TRIM21 expression by small interfering RNA inhibited this differentiation. In conclusion, TRIM21 played a pivotal role in regulating the secretion of proinflammatory cytokines in monocytes of BD patients.
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DOI
10.1038/s41598-017-03251-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
김도영(Kim, Do Young) ORCID logo https://orcid.org/0000-0002-0194-9854
방동식(Bang, Dong Sik)
정진룡(Zheng, Zhen Long)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160229
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