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Serum high-density lipoprotein cholesterol concentration and functional state: The Korean Urban Rural Elderly (KURE) Study

Authors
 Hansol Choi  ;  Hyeon Chang Kim  ;  Katherine M. Stefani  ;  Ju-Mi Lee  ;  Young Mi Yoon  ;  Eun Young Lee  ;  Kyoung Min Kim  ;  Yumie Rhee  ;  Yoosik Youm  ;  Chang Oh Kim 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.71 : 115-121, 2017 
Journal Title
 ARCHIVES OF GERONTOLOGY AND GERIATRICS 
ISSN
 0167-4943 
Issue Date
2017
MeSH
Activities of Daily Living* ; Aged ; Cholesterol, HDL/blood* ; Cohort Studies ; Cross-Sectional Studies ; Female ; Geriatric Assessment* ; Humans ; Logistic Models ; Male ; Rural Population
Keywords
Cognitive function ; Elderly ; Functional state ; HDL cholesterol ; Physical function
Abstract
BACKGROUND: Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. METHODS: This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015. HDL cholesterol concentration was analyzed using both continuous and categorical variables. Functional state was assessed by the mini-mental state examination (MMSE), activities of daily living (ADL) scale, instrumental activities of daily living (IADL) scale, timed up-and go (TUG) test, and chair-rise test (CRT). Multiple logistic regression models were used to investigate independent association between HDL cholesterol and functional state, after adjusting for sex, age, body mass index, systolic blood pressure, fasting glucose, lipid-lowering drug, history of cancer and cardiovascular disease, and health behaviors. RESULTS: HDL cholesterol concentration was significantly associated with MMSE, ADL, IADL, TUG, and CRT in the unadjusted model. After adjustment for covariates, the association remained significant for MMSE (standardized β=0.059, p=0.001), ADL (standardized β=-0.053, p=0.004), and CRT (standardized β=-0.037, p=0.037). In fully-adjusted model, Participants who had a lower HDL concentration (<40mg/dL) showed significantly increased odds for having MMSE decline (OR 1.451, 95% CI 1.119-1.883) and ADL dependency (OR 2.251, 95% CI 1.119-4.526), compared reference group (≥60mg/dL). CONCLUSIONS: Higher HDL cholesterol concentration was associated with better functional state among Korean older adults.
Full Text
https://www.sciencedirect.com/science/article/pii/S0167494317302091
DOI
10.1016/j.archger.2017.04.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Eun Young(이은영)
Lee, Ju Mi(이주미)
Choi, Han Sol(최한솔)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160213
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