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Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans

Authors
 Eun Young Lee  ;  Su Jin Lee  ;  Kyoung Min Kim  ;  Young Mi Yun  ;  Bo Mi Song  ;  Jong Eun Kim  ;  Hyeon Chang Kim  ;  Yumie Rhee  ;  Yoosik Youm  ;  Chang Oh Kim 
Citation
 GERIATRICS & GERONTOLOGY INTERNATIONAL, Vol.17(7) : 1069-1075, 2017 
Journal Title
 GERIATRICS & GERONTOLOGY INTERNATIONAL 
ISSN
 1444-1586 
Issue Date
2017
Keywords
cognitive impairment ; elderly ; metabolic syndrome ; vitamin D
Abstract
AIM: Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults. METHODS: We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25-49, 50-74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. RESULTS: Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61-5.80) when compared with those with no metabolic syndrome and high 25(OH)D. CONCLUSIONS: Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/ggi.12826
DOI
10.1111/ggi.12826
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Su Jin(이수진) ORCID logo https://orcid.org/0000-0002-7325-2538
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160193
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