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Effect of Korean Red Ginseng on Artificial Sand Dust(ASD) Induced Allergic Lung Inflammation

Authors
 Jung-Ha Kim  ;  Tae-Jin Lee  ;  Im Jee-Aee  ;  Duk-Chul Lee 
Citation
 Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.20(3) : 173-179, 2014 
Journal Title
 Journal of Experimental & Biomedcal Science (대한의생명과학회지) 
ISSN
 1738-3226 
Issue Date
2014
Keywords
Asian sand dust ; Korean red ginseng ; Anti-inflammation ; Allergic mouse model
Abstract
Asian sand dust is known to promote various respiratory symptoms or disorders. For the prevention of harmful health effects by Asian sand dust, the best strategy is known to avoid or reduce exposure to the Asian sand dust. Several studies have shown that Korean red ginseng (RG) has anti-inflammatory and anti-allergic effects. The study aimed to clarify the effect of Korean red ginseng intake on lung inflammation responses to artificial sand dust (ASD) similar to Asian sand dust. BALB/c mice were divided into five groups (n=12) of control (saline), ovalbumin (OVA), OVA with ASD, OVA plus RG with ASD, and OVA plus dexamethasone (DEXA) with ASD. Histopathologic evaluation of lung was conducted. Interleukin (IL)-5, IL-12, interferon (IFN)-γ, IL-13, monocyte chemotactic protein (MCP)-1, and eotaxin within bronchoalveolar lavage (BAL) fluid were measured by ELISA. OVA+ASD group significantly increased concentrations of IL-5, IL-13, MCP-1, and eotaxin (P<0.01) compared to the control. OVA+ASD+RG group showed significant decreased levels of IL-2, IL-13, MCP-1 and eotaxin (P<0.01) compared with OVA+ASD. Between RG and DEXA treatment groups, there was no significant difference in all cytokines and chemokines. The inflammatory cells were significantly decreased in treatment groups with RG or DEXA compared to OVA+ASD group. This study suggests a beneficial effect of Korean RG administration in preventing inflammation of lung resulting from Asian sand dust.
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DOI
10.15616/BSL.2014.20.3.173
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
이덕철(Lee, Duk Chul) ORCID logo https://orcid.org/0000-0001-9166-1813
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158589
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