Manipulative therapy is a non-surgical treatment modality that includes the use of skilled hands directed to the patient’s spine and extremities for the purpose of treating and restoring a variety of symptoms and conditions. Manipulative therapy constitutes a wide variety of different techniques which may be categorized as follows: manipulation (thrust manipulation), mobilization (non-thrust manipulation within range of motion), static stretching, and muscle energy techniques. The conditions which responded moderately (positively) to manipulative therapy include: frozen shoulder, myofascial pain syndrome, plnatar fasciitis, cervicogenic headache, and cervicogenic dizziness. Further research is warranted for evaluating the effectiveness and mechanism of manipulative therapy for skeletal and non-skeletal diseases.