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Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells

Authors
 Un Yung Choi  ;  Ji Yeon Hur  ;  Myeong Sup Lee  ;  Quanri Zhang  ;  Won Young Choi  ;  Lark Kyun Kim  ;  Wook-Bin Lee  ;  Goo Taeg Oh  ;  Young-Joon Kim 
Citation
 PLOS ONE, Vol.9(4) : e95805, 2014 
Journal Title
PLOS ONE
Issue Date
2014
MeSH
Age Factors ; Animals ; CD4-CD8 Ratio ; CD4-Positive T-Lymphocytes/immunology* ; CD4-Positive T-Lymphocytes/metabolism* ; Carrier Proteins/genetics* ; Carrier Proteins/metabolism ; Cell Cycle/genetics ; Homeodomain Proteins/genetics ; Lymphocyte Activation/genetics* ; Lymphocyte Activation/immunology* ; Male ; Mice ; Mice, Knockout ; NF-kappa B/metabolism ; Receptors, Antigen, T-Cell/metabolism*
Abstract
To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30-/-) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in the activation of macrophages. But, Trim30-/- mice showed increased CD4/CD8 ratio when aged and Trim30-/- CD4+ T cells exhibited an abnormal response upon TCR activation, in particular in the absence of a costimulatory signal. Adoptive transfer of wild-type and Trim30-/- CD4+ T cells together into lymphopenic hosts confirmed higher proliferation of the Trim30-/- CD4+ T cells in vivo. Despite the enhanced proliferation, Trim30-/- T cells showed decreased levels of NF-κB activation and IL-2 production compared to wild-type cells. These results indicate a distinct requirement for TRIM30 in modulation of NF-κB activation and cell proliferation induced by TCR stimulation.
Files in This Item:
T201401980.pdf Download
DOI
10.1371/journal.pone.0095805
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158558
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