Cited 18 times in
Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells
DC Field | Value | Language |
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dc.contributor.author | 김락균 | - |
dc.date.accessioned | 2018-05-10T06:44:53Z | - |
dc.date.available | 2018-05-10T06:44:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158558 | - |
dc.description.abstract | To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30-/-) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in the activation of macrophages. But, Trim30-/- mice showed increased CD4/CD8 ratio when aged and Trim30-/- CD4+ T cells exhibited an abnormal response upon TCR activation, in particular in the absence of a costimulatory signal. Adoptive transfer of wild-type and Trim30-/- CD4+ T cells together into lymphopenic hosts confirmed higher proliferation of the Trim30-/- CD4+ T cells in vivo. Despite the enhanced proliferation, Trim30-/- T cells showed decreased levels of NF-κB activation and IL-2 production compared to wild-type cells. These results indicate a distinct requirement for TRIM30 in modulation of NF-κB activation and cell proliferation induced by TCR stimulation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD4-CD8 Ratio | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/metabolism* | - |
dc.subject.MESH | Carrier Proteins/genetics* | - |
dc.subject.MESH | Carrier Proteins/metabolism | - |
dc.subject.MESH | Cell Cycle/genetics | - |
dc.subject.MESH | Homeodomain Proteins/genetics | - |
dc.subject.MESH | Lymphocyte Activation/genetics* | - |
dc.subject.MESH | Lymphocyte Activation/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Receptors, Antigen, T-Cell/metabolism* | - |
dc.title | Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Un Yung Choi | - |
dc.contributor.googleauthor | Ji Yeon Hur | - |
dc.contributor.googleauthor | Myeong Sup Lee | - |
dc.contributor.googleauthor | Quanri Zhang | - |
dc.contributor.googleauthor | Won Young Choi | - |
dc.contributor.googleauthor | Lark Kyun Kim | - |
dc.contributor.googleauthor | Wook-Bin Lee | - |
dc.contributor.googleauthor | Goo Taeg Oh | - |
dc.contributor.googleauthor | Young-Joon Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0095805 | - |
dc.contributor.localId | A04520 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24756037 | - |
dc.contributor.alternativeName | Kim, Lark Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Lark Kyun | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e95805 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(4) : e95805, 2014 | - |
dc.identifier.rimsid | 43143 | - |
dc.type.rims | ART | - |
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