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Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation

Authors
 Eun Sam Rho  ;  Earl Kim  ;  Hong Koh  ;  Han-Wook Yoo  ;  Beom Hee Lee  ;  Gu-Hwan Kim 
Citation
 Korean Journal of Pediatrics, Vol.56(5) : 227-230, 2013 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2013
Keywords
Anomalous pancreaticobiliary ductal union ; Chronic pancreatitis ; Kazal type 1 ; Serine protease inhibitor
Abstract
Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine-protease inhibitor, Kazal type 1 (SPINK1), cationic trypsinogen (PRSS1), and cystic fibrosis-transmembrane conductance regulator (CFTR) genes, or with structural disorders in the pancreaticobiliary ductal system, such as pancreatic divisum or anomalous pancreaticobiliary ductal union (APBDU). However, it is unusual to observe both genetic alteration and structural anomaly. Here, we report 2 cases with both APBDU and a mutation in the SPINK1 genes, and we discuss the implications of these findings in clinical practice.
Files in This Item:
T201306229.pdf Download
DOI
10.3345/kjp.2013.56.5.227
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158495
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