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The efficacy of aspartate aminotransferase-to-platelet ratio index for assessing hepatic fibrosis in childhood nonalcoholic steatohepatitis for medical practice

DC FieldValueLanguage
dc.contributor.author강윤구-
dc.contributor.author고홍-
dc.contributor.author박영년-
dc.contributor.author이미정-
dc.contributor.author한승민-
dc.date.accessioned2018-05-10T06:40:09Z-
dc.date.available2018-05-10T06:40:09Z-
dc.date.issued2013-
dc.identifier.issn1738-1061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158403-
dc.description.abstractPURPOSE: Childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), and it has become one of the most common causes of childhood chronic liver diseases which significant as a cause of liver related mortality and morbidity in children in the United States. The development of simpler and easier clinical indices for medical practice is needed to identify advanced hepatic fibrosis in childhood NAFLD instead of invasive method like liver biopsy. FibroScan and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) have been proposed as a simple and noninvasive predictor to evaluate hepatic fibrosis in several liver diseases. APRI could be a good alternative to detect pathologic change in childhood NAFLD. The purpose of this study is to validate the efficacy of APRI for assessing hepatic fibrosis in childhood NAFLD based on FibroScan. METHODS: This study included 23 children with NAFLD who underwent FibroScan. Clinical, laboratory and radiological evaluation including APRI was performed. To confirm the result of this study, 6 patients received liver biopsy. RESULTS: Factors associated with hepatic fibrosis (stiffness measurement >5.9 kPa Fibroscan) were triglyceride, AST, alanine aminotransferase, platelet count, APRI and collagen IV. In multivariate analysis, APRI were correlated with hepatic fibrosis (>5.9 kPa). In receiver operating characteristics curve, APRI of meaningful fibrosis (cutoff value, 0.4669; area under the receiver operating characteristics, 0.875) presented sensitivity of 94%, specificity of 66%, positive predictive value of 94%, and negative predictive value of 64%. CONCLUSION: APRI might be a noninvasive, simple, and readily available method for medical practice to predict hepatic fibrosis of childhood NAFLD.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한소아과학회-
dc.relation.isPartOfKorean Journal of Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe efficacy of aspartate aminotransferase-to-platelet ratio index for assessing hepatic fibrosis in childhood nonalcoholic steatohepatitis for medical practice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorEarl Kim-
dc.contributor.googleauthorYunkoo Kang-
dc.contributor.googleauthorSeungmin Hahn-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorHong Koh-
dc.contributor.localIdA05213-
dc.contributor.localIdA00156-
dc.contributor.localIdA01563-
dc.contributor.localIdA02774-
dc.contributor.localIdA04299-
dc.relation.journalcodeJ02100-
dc.identifier.eissn2092-7258-
dc.subject.keywordAPRI-
dc.subject.keywordChild-
dc.subject.keywordHepatic fibrosis-
dc.subject.keywordNonalcoholic fatty liver disease-
dc.contributor.alternativeNameKang, Yunkoo-
dc.contributor.alternativeNameKoh, Hong-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameHahn, Seung Min-
dc.contributor.affiliatedAuthorKang, Yunkoo-
dc.contributor.affiliatedAuthorKoh, Hong-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorHahn, Seung Min-
dc.citation.volume56-
dc.citation.number1-
dc.citation.startPage19-
dc.citation.endPage25-
dc.identifier.bibliographicCitationKorean Journal of Pediatrics, Vol.56(1) : 19-25, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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