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LAR-RPTPs: synaptic adhesion molecules that shape synapse development

Authors
 Ji Won Um  ;  Jaewon Ko 
Citation
 TRENDS IN CELL BIOLOGY, Vol.23(10) : 465-475, 2013 
Journal Title
 TRENDS IN CELL BIOLOGY 
ISSN
 0962-8924 
Issue Date
2013
MeSH
Cell Adhesion Molecules/metabolism* ; Central Nervous System/growth & development* ; Central Nervous System/metabolism ; Humans ; Membrane Proteins ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/genetics ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/metabolism* ; Synapses/metabolism ; Synapses/physiology*
Abstract
The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.
Full Text
https://www.sciencedirect.com/science/article/pii/S0962892413001153
DOI
10.1016/j.tcb.2013.07.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Um, Ji Won(엄지원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158379
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