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LAR-RPTPs: synaptic adhesion molecules that shape synapse development

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dc.contributor.author엄지원-
dc.date.accessioned2018-05-10T06:39:12Z-
dc.date.available2018-05-10T06:39:12Z-
dc.date.issued2013-
dc.identifier.issn0962-8924-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158379-
dc.description.abstractThe synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEngland-
dc.publisher1879-3088-
dc.relation.isPartOfTRENDS IN CELL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Adhesion Molecules/metabolism*-
dc.subject.MESHCentral Nervous System/growth & development*-
dc.subject.MESHCentral Nervous System/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMembrane Proteins-
dc.subject.MESHNerve Tissue Proteins/metabolism-
dc.subject.MESHNeurons/metabolism-
dc.subject.MESHReceptor-Like Protein Tyrosine Phosphatases, Class 2/genetics-
dc.subject.MESHReceptor-Like Protein Tyrosine Phosphatases, Class 2/metabolism*-
dc.subject.MESHSynapses/metabolism-
dc.subject.MESHSynapses/physiology*-
dc.titleLAR-RPTPs: synaptic adhesion molecules that shape synapse development-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Physiology-
dc.contributor.googleauthorJi Won Um-
dc.contributor.googleauthorJaewon Ko-
dc.identifier.doi10.1016/j.tcb.2013.07.004-
dc.contributor.localIdA02340-
dc.relation.journalcodeJ03311-
dc.identifier.eissn1879-3088-
dc.identifier.pmid23916315-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0962892413001153-
dc.contributor.alternativeNameUm, Ji Won-
dc.contributor.affiliatedAuthorUm, Ji Won-
dc.citation.volume23-
dc.citation.number10-
dc.citation.startPage465-
dc.citation.endPage475-
dc.identifier.bibliographicCitationTRENDS IN CELL BIOLOGY, Vol.23(10) : 465-475, 2013-
dc.identifier.rimsid40737-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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