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Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2

 Hyunmin Choi  ;  No-Je Park  ;  Otgonbold Jamiyandorj  ;  Kyung-Hee Choi  ;  Min-Ho Hong  ;  Seunghan Oh  ;  Young-Bum Park  ;  Sungtae Kim 
 Journal of Periodontal & Implant Science, Vol.42(4) : 119-126, 2012 
Journal Title
 Journal of Periodontal & Implant Science 
Issue Date
Bone morphogenetic protein 2 ; Bone regeneration ; Bone substitute ; Maxillary sinus ; Rabbits
Purpose : The aim of this study was to determine whether biphasic calcium phosphate (BCP) bone substitute with two different concentrations of Escherichia coli-expressed recombinant human bone morphogenetic protein 2 (ErhBMP-2) enhances new bone formation in a standardized rabbit sinus model and to evaluate the concentration-dependent effect of ErhBMP-2. Methods : Standardized, 6-mm diameter defects were made bilaterally on the maxillary sinus of 20 male New Zealand white rabbits. Following removal of the circular bony windows and reflection of the sinus membrane, BCP bone substitute without coating (control group) was applied into one defect and BCP bone substitute coated with ErhBMP-2 (experimental group) was applied into the other defect for each rabbit. The experimental group was divided into 2 subgroups according to the concentration of ErhBMP-2 (0.05 and 0.5 mg/mL). The animals were allowed to heal for either 4 or 8 weeks and sections of the augmented sinus and surrounding bone were analyzed by microcomputed tomography and histologically. Results : Histologic analysis revealed signs of new bone formation in both the control and experimental groups with a statistically significant increase in bone formation in experimental group 1 (0.05 mg/mL ErhBMP-2 coating) after a 4-week healing period. However, no statistically significant difference was found between experimental group 1 and experimental group 2 (0.5 mg/mL ErhBMP-2 coating) in osteoinductive potential (P<0.05). Conclusions : ErhBMP-2 administered using a BCP matrix significantly enhanced osteoinductive potential in a standardized rabbit sinus model. A concentration-dependent response was not found in the present study.
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1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)
Yonsei Authors
박영범(Park, Young Bum)
최현민(Choi, Hyun Min)
홍민호(Hong, Min Ho)
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