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Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2

DC Field Value Language
dc.contributor.author박영범-
dc.contributor.author최현민-
dc.contributor.author홍민호-
dc.date.accessioned2018-05-10T06:36:24Z-
dc.date.available2018-05-10T06:36:24Z-
dc.date.issued2012-
dc.identifier.issn2093-2278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158290-
dc.description.abstractPurpose : The aim of this study was to determine whether biphasic calcium phosphate (BCP) bone substitute with two different concentrations of Escherichia coli-expressed recombinant human bone morphogenetic protein 2 (ErhBMP-2) enhances new bone formation in a standardized rabbit sinus model and to evaluate the concentration-dependent effect of ErhBMP-2. Methods : Standardized, 6-mm diameter defects were made bilaterally on the maxillary sinus of 20 male New Zealand white rabbits. Following removal of the circular bony windows and reflection of the sinus membrane, BCP bone substitute without coating (control group) was applied into one defect and BCP bone substitute coated with ErhBMP-2 (experimental group) was applied into the other defect for each rabbit. The experimental group was divided into 2 subgroups according to the concentration of ErhBMP-2 (0.05 and 0.5 mg/mL). The animals were allowed to heal for either 4 or 8 weeks and sections of the augmented sinus and surrounding bone were analyzed by microcomputed tomography and histologically. Results : Histologic analysis revealed signs of new bone formation in both the control and experimental groups with a statistically significant increase in bone formation in experimental group 1 (0.05 mg/mL ErhBMP-2 coating) after a 4-week healing period. However, no statistically significant difference was found between experimental group 1 and experimental group 2 (0.5 mg/mL ErhBMP-2 coating) in osteoinductive potential (P<0.05). Conclusions : ErhBMP-2 administered using a BCP matrix significantly enhanced osteoinductive potential in a standardized rabbit sinus model. A concentration-dependent response was not found in the present study.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Academy of Periodontology-
dc.relation.isPartOfJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImprovement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Prosthodontics-
dc.contributor.googleauthorHyunmin Choi-
dc.contributor.googleauthorNo-Je Park-
dc.contributor.googleauthorOtgonbold Jamiyandorj-
dc.contributor.googleauthorKyung-Hee Choi-
dc.contributor.googleauthorMin-Ho Hong-
dc.contributor.googleauthorSeunghan Oh-
dc.contributor.googleauthorYoung-Bum Park-
dc.contributor.googleauthorSungtae Kim-
dc.identifier.doi10.5051/jpis.2012.42.4.119-
dc.contributor.localIdA01567-
dc.contributor.localIdA04208-
dc.contributor.localIdA04392-
dc.relation.journalcodeJ01695-
dc.identifier.eissn2093-2286-
dc.identifier.pmid22977741-
dc.subject.keywordBone morphogenetic protein 2-
dc.subject.keywordBone regeneration-
dc.subject.keywordBone substitute-
dc.subject.keywordMaxillary sinus-
dc.subject.keywordRabbits-
dc.contributor.alternativeNamePark, Young Bum-
dc.contributor.alternativeNameChoi, Hyun Min-
dc.contributor.alternativeNameHong, Min Ho-
dc.contributor.affiliatedAuthorPark, Young Bum-
dc.contributor.affiliatedAuthorChoi, Hyun Min-
dc.contributor.affiliatedAuthorHong, Min Ho-
dc.citation.volume42-
dc.citation.number4-
dc.citation.startPage119-
dc.citation.endPage126-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.42(4) : 119-126, 2012-
dc.identifier.rimsid40666-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers

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