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뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자

Other Titles
 Biochemical Biomarkers for Alzheimer’s Disease in Cerebrospinal Fluid and Peripheral Blood 
Authors
 이영민  ;  최원정  ;  박민선  ;  김어수 
Citation
 Journal of Korean Geriatric Psychiatry (노인정신의학), Vol.16(1) : 17-23, 2012 
Journal Title
 Journal of Korean Geriatric Psychiatry (노인정신의학) 
ISSN
 1226-6329 
Issue Date
2012
MeSH
Aged ; Alzheimer Disease ; Biomarkers ; Brain ; Humans ; Mild Cognitive Impairment ; Plasma ; Specialization ; Spinal Puncture
Keywords
알츠하이머병 ; 생체표지자 ; 베타 아밀로이드 ; 타 우 ; 오믹스 ; 혈장 ; Alzheimer’s disease ; Biomarker ; Beta-amyloid ; Tau ; Omics ; Plasma
Abstract
The diagnosis of Alzheimer's disease (AD) is still obscure even to specialists. To improve the diagnostic accuracy, to find at-risk people as early as possible, to predict the efficacy or adverse reactions of pharmacotherapy on an individual basis, to attain more reliable results of clinical trials by recruiting better defined participants, to prove the disease-modifying ability of new candidate drugs, to establish prognosis-based therapeutic plans, and to do more, is now increasing the need for biomarkers for AD. Among AD-related biochemical markers, cerebrospinal beta-amyloid and tau have been paid the most attention since they are materials directly interfacing the brain interstitium and can be obtained through the lumbar puncture. Level of beta-amyloid is reduced whereas tau is increased in cerebrospinal fluid of AD patients relative to cognitively normal elderly people. Remarkably, such information has been found to help predict AD conversion of mild cognitive impairment. Despite inconsistent findings from previous studies, plasma beta-amyloid is thought to be increased before the disease onset, but show decreasing change as the disease progress. Regarding other peripheral biochemical markers, omics tools are being widely used not only to find useful biomarkers but also to generate novel hypotheses for AD pathogenesis and to lead new personalized future medicine.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010023460486
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Behavioral Sciences in Medicine (의학행동과학연구소) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
박민선(Park, Min Sun)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158288
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