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VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia

Authors
 Jaehyung Kim  ;  Jinhyung Kim  ;  Kyou Sik Min  ;  Sung Eun Lee  ;  Sung June Kim  ;  Jin Woo Chang 
Citation
 NEUROLOGICAL SCIENCES, Vol.33(6) : 1265-1270, 2012 
Journal Title
NEUROLOGICAL SCIENCES
ISSN
 1590-1874 
Issue Date
2012
MeSH
Animals ; Cold Temperature/adverse effects* ; Deep Brain Stimulation/methods* ; Disease Models, Animal* ; Hyperalgesia/physiopathology ; Hyperalgesia/therapy* ; Male ; Neuralgia/physiopathology ; Neuralgia/therapy* ; Pain Measurement/methods ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Ventral Thalamic Nuclei/physiology*
Abstract
Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: naïve (naïve, n = 10), naïve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p < 0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p > 0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.
Full Text
https://link.springer.com/article/10.1007/s10072-012-1097-7
DOI
10.1007/s10072-012-1097-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jin Hyung(김진형)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158259
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