0 467

Cited 20 times in

Modification of TiO(2) nanotube surfaces by electro-spray deposition of amoxicillin combined with PLGA for bactericidal effects at surgical implantation sites

Authors
 Jung-Hwan Lee  ;  Seung-Kyun Moon  ;  Kwang-Mahn Kim  ;  Kyoung-Nam Kim 
Citation
 ACTA ODONTOLOGICA SCANDINAVICA, Vol.71(1) : 168-174, 2013 
Journal Title
ACTA ODONTOLOGICA SCANDINAVICA
ISSN
 0001-6357 
Issue Date
2013
MeSH
3T3 Cells ; Amoxicillin/administration & dosage* ; Amoxicillin/analysis ; Animals ; Anti-Bacterial Agents/administration & dosage* ; Anti-Bacterial Agents/analysis ; Bone Plates/microbiology ; Cell Adhesion ; Cell Proliferation ; Coated Materials, Biocompatible/administration & dosage* ; Coated Materials, Biocompatible/analysis ; Dental Implantation, Endosseous/methods* ; Dental Implants*/microbiology ; Drug Combinations ; Lactic Acid/administration & dosage* ; Lactic Acid/analysis ; Mice ; Nanotubes ; Osteoblasts ; Polyglycolic Acid/administration & dosage* ; Polyglycolic Acid/analysis ; Spectrophotometry ; Spectroscopy, Fourier Transform Infrared ; Staphylococcal Infections/prevention & control* ; Staphylococcus aureus/drug effects ; Surface Properties ; Titanium
Keywords
implant surface coating ; electro spray deposition ; amoxicillin ; PLGA
Abstract
OBJECTIVE: To fabricate the antibiotic-releasing coatings on TiO(2) nanotube surfaces for wide applications of implant and bone plate in medical and dental surgery, the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures was found.

MATERIALS AND METHODS: FE-SEM, ESD and FT-IR were used for confirming deposition of amoxicillin/PLGA on the TiO(2) surface. Also, the elution of amoxicillin/PLGA in a TiO(2) nanotube surface was measured by a UV-VIS spectrophotometer. The bactericidal effect of amoxicillin on the TiO(2) nanotube surface was evaluated by using Staphylococcus aureus (S. aureus). The cytotoxicity and cell proliferation were observed by WST assay using MC3T3-E1 osteoblast cells.

RESULTS: The results indicated that the TiO(2) nanotube surface controlled by electro-spray deposition time with amoxicillin/PLGA solution could provide a high bactericidal effect against S. aureus by the bactericidal effect of amoxicillin, as well as good osteoblast cell proliferation at the TiO(2) nanotube surface without toxicity.

CONCLUSIONS: This study used electro-spray deposition (ESD) methodology to obtain amoxicillin deposition in nanotube structures of TiO(2) and found the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures.
Full Text
http://www.tandfonline.com/doi/full/10.3109/00016357.2011.654256
DOI
10.3109/00016357.2011.654256
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Moon, Seung Kyun(문승균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158248
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links