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The role of surgical treatment in second primary lung cancer

 Mi Kyung Bae  ;  Chun Sung Byun  ;  Chang Young Lee  ;  Jin Gu Lee  ;  In Kyu Park  ;  Dae Joon Kim  ;  Kyung Young Chung 
 ANNALS OF THORACIC SURGERY, Vol.92(1) : 256-262, 2011 
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Aged ; Biopsy, Needle ; Chemotherapy, Adjuvant ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality* ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Neoplasms, Second Primary/mortality* ; Neoplasms, Second Primary/pathology ; Neoplasms, Second Primary/surgery* ; Pneumonectomy/methods ; Prognosis ; Radiotherapy, Adjuvant ; Reoperation/methods ; Retrospective Studies ; Survival Analysis ; LinkOut - more resou
BACKGROUND : This study was designed to assess the treatment of patients in whom a second primary lung cancer developed after the resection of primary lung cancer. METHODS : Between January 1990 and December 2008, 1852 patients underwent complete resection for primary lung cancer in our institution. Of these individuals, patients who had been identified as having a second primary lung cancer by December 2009 were selected for this study using the criteria proposed by Martini and Melamed. RESULTS : Of 1852 patients, a second primary lung cancer developed in 40 (2.2%) during the follow-up period. The overall 5-year and 10-year survival rates after the resection of the first tumor were 78.3% and 39.9%, respectively. The overall 5-year survival rate from the time of detection of the second primary lung cancer was 47.8%, and the 5-year survival rate of the patients who underwent resection of the second tumor was 77.0%. The patients who underwent sublobar resection had comparable overall survival and disease-free survival compared with the patients who underwent anatomic resection. Additionally, the patients who underwent sublobar resection had a better operative outcome. CONCLUSIONS : Surgical resection is feasible and effective in the management of second primary lung cancer, and sublobar resection may be adequate. Long-term surveillance of more than 5 years is essential for early detection to increase the chance of resection of a second primary lung cancer.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Bae, Mi Kyung(배미경)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
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