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Hepatic stellate cells and innate immunity in alcoholic liver disease

Authors
 Yang-Gun Suh  ;  Won-Il Jeong 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.17(20) : 2543-2551, 2011 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2011
MeSH
Fatty Liver/etiology ; Fatty Liver/physiopathology ; Fatty Liver/prevention & control ; Hepatic Stellate Cells/physiology* ; Humans ; Immunity, Innate/physiology* ; Liver Cirrhosis/etiology ; Liver Cirrhosis/physiopathology ; Liver Cirrhosis/prevention & control ; Liver Diseases, Alcoholic/etiology ; Liver Diseases, Alcoholic/physiopathology* ; Liver Diseases, Alcoholic/prevention & control
Keywords
Alcoholic liver disease ; Endocannabinoid ; Fibrosis ; Hepatic stellate cell ; Kupffer cell ; Natural killer cell ; Steatohepatitis ; Steatosis
Abstract
Constant alcohol consumption is a major cause of chronic liver disease, and there has been a growing concern regarding the increased mortality rates worldwide. Alcoholic liver diseases (ALDs) range from mild to more severe conditions, such as steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The liver is enriched with innate immune cells (e.g. natural killer cells and Kupffer cells) and hepatic stellate cells (HSCs), and interestingly, emerging evidence suggests that innate immunity contributes to the development of ALDs (e.g. steatohepatitis and liver fibrosis). Indeed, HSCs play a crucial role in alcoholic steatosis via production of endocannabinoid and retinol metabolites. This review describes the roles of the innate immunity and HSCs in the pathogenesis of ALDs, and suggests therapeutic targets and strategies to assist in the reduction of ALD.
Files in This Item:
T201194406.pdf Download
DOI
10.3748/wjg.v17.i20.2543
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Suh, Yang Gun(서양권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158164
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