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Hepatic stellate cells and innate immunity in alcoholic liver disease

DC FieldValueLanguage
dc.contributor.author서양권-
dc.date.accessioned2018-05-10T06:32:47Z-
dc.date.available2018-05-10T06:32:47Z-
dc.date.issued2011-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158164-
dc.description.abstractConstant alcohol consumption is a major cause of chronic liver disease, and there has been a growing concern regarding the increased mortality rates worldwide. Alcoholic liver diseases (ALDs) range from mild to more severe conditions, such as steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The liver is enriched with innate immune cells (e.g. natural killer cells and Kupffer cells) and hepatic stellate cells (HSCs), and interestingly, emerging evidence suggests that innate immunity contributes to the development of ALDs (e.g. steatohepatitis and liver fibrosis). Indeed, HSCs play a crucial role in alcoholic steatosis via production of endocannabinoid and retinol metabolites. This review describes the roles of the innate immunity and HSCs in the pathogenesis of ALDs, and suggests therapeutic targets and strategies to assist in the reduction of ALD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBaishideng Publishing Group-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHFatty Liver/etiology-
dc.subject.MESHFatty Liver/physiopathology-
dc.subject.MESHFatty Liver/prevention & control-
dc.subject.MESHHepatic Stellate Cells/physiology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunity, Innate/physiology*-
dc.subject.MESHLiver Cirrhosis/etiology-
dc.subject.MESHLiver Cirrhosis/physiopathology-
dc.subject.MESHLiver Cirrhosis/prevention & control-
dc.subject.MESHLiver Diseases, Alcoholic/etiology-
dc.subject.MESHLiver Diseases, Alcoholic/physiopathology*-
dc.subject.MESHLiver Diseases, Alcoholic/prevention & control-
dc.titleHepatic stellate cells and innate immunity in alcoholic liver disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorYang-Gun Suh-
dc.contributor.googleauthorWon-Il Jeong-
dc.identifier.doi10.3748/wjg.v17.i20.2543-
dc.contributor.localIdA01891-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid21633659-
dc.subject.keywordAlcoholic liver disease-
dc.subject.keywordEndocannabinoid-
dc.subject.keywordFibrosis-
dc.subject.keywordHepatic stellate cell-
dc.subject.keywordKupffer cell-
dc.subject.keywordNatural killer cell-
dc.subject.keywordSteatohepatitis-
dc.subject.keywordSteatosis-
dc.contributor.alternativeNameSuh, Yang Gun-
dc.contributor.affiliatedAuthorSuh, Yang Gun-
dc.citation.volume17-
dc.citation.number20-
dc.citation.startPage2543-
dc.citation.endPage2551-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.17(20) : 2543-2551, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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