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European 1: a globally important clonal complex of Mycobacterium bovis

Authors
 Noel H. Smith  ;  Stefan Berg  ;  James Dale  ;  Adrian Allen  ;  Sabrina Rodriguez  ;  Beatriz Romero  ;  Filipa Matos  ;  Solomon Ghebremichael  ;  Claudine Karoui  ;  Chiara Donati  ;  Adelina da Conceicao Machado  ;  Custodia Mucavele  ;  Rudovick R. Kazwala  ;  Markus Hilty  ;  Simeon Cadmus  ;  Bongo Nare´ Richard Ngandolom  ;  Meseret Habtamu  ;  James Oloya  ;  Anne´ lle Muller  ;  Feliciano Milian-Suazo  ;  Olga Andrievskaia  ;  Michaela Projahn  ;  Soledad Barandiara´n  ;  Analı´a Macı´as  ;  Borna Mu¨ ller  ;  Marcos Santos Zanini  ;  Cassia Yumi Ikuta  ;  Cesar Alejandro Rosales Rodriguez  ;  Soˆnia Regina Pinheiro  ;  Alvaro Figueroa  ;  Sang-Nae Cho  ;  Nader Mosavari  ;  Pei-Chun Chuang  ;  Ruwen Jou 
Citation
 INFECTION GENETICS AND EVOLUTION, Vol.11(6) : 1340-1351, 2011 
Journal Title
INFECTION GENETICS AND EVOLUTION
ISSN
 1567-1348 
Issue Date
2011
MeSH
Africa/epidemiology ; Americas/epidemiology ; Animals ; Asia/epidemiology ; Australasia/epidemiology ; Cattle ; Chromosome Deletion ; Europe/epidemiology ; Mycobacterium bovis/genetics* ; Phylogeography ; Polymorphism, Genetic ; Sequence Analysis, DNA ; Tuberculosis, Bovine/epidemiology*
Keywords
World ; Bovine tuberculosis ; Clonal complex ; Localisation ; Cattle ; Phylogeography ; Mycobacterium bovis
Abstract
We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.
Full Text
https://www.sciencedirect.com/science/article/pii/S156713481100133X
DOI
10.1016/j.meegid.2011.04.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158153
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