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Options for successful renal transplantation in recipients with incompatible living donors: Severance Hospital experience

Authors
 Huh KH  ;  Kim MS  ;  Kim YS  ;  Kim HJ  ;  Kim HJ  ;  Kim HO  ;  Yoo TH  ;  Kim SI  ;  Park K 
Citation
 Clinical Transplants, : 323-326, 2010 
Journal Title
 Clinical Transplants 
ISSN
 0890-9016 
Issue Date
2010
MeSH
ABO Blood-Group System/immunology* ; Academic Medical Centers* ; Blood Group Incompatibility* ; Blood Grouping and Crossmatching ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival ; Histocompatibility* ; Humans ; Kidney Transplantation/immunology* ; Living Donors* ; Program Development ; Program Evaluation ; Republic of Korea ; Time Factors ; Tissue and Organ Procurement ; Treatment Outcome
Abstract
Exchange donor programs and desensitization protocols are available options for ABO-incompatible and positive cross-match living donor kidney transplantations. Patient and donor blood types, the degree of sensitization, and DSA titers should be considered to achieve successful kidney transplantation in recipients with incompatible living donors. Highly sensitized blood type O patients with ABO-incompatible living donors, or highly sensitized patients with a positive cross-match (with low DSA titer) to their AB donors should be considered for a desensitization protocol as a first priority. Narrowly sensitized patients with a positive cross-match (and high DSA titer) should be considered for an exchange donor program if possible. Patients with positive cross-match O donors can be easily matched and benefit from an exchange program. Exchange donor programs and desensitization protocols are complementary strategies to overcome HLA and ABO antibody barriers.
Full Text
https://terasaki.org/store/CH29-Huh
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158126
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