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Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients

 Tae-Jin Song  ;  Yoonkyung Chang  ;  Min-Jeong Shin  ;  Ji Hoe Heo  ;  Yong-Jae Kim 
 NUTRITION RESEARCH, Vol.35(5) : 368-374, 2015 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Brain Ischemia/epidemiology ; Brain Ischemia/etiology* ; Cerebral Infarction/blood ; Cerebral Infarction/pathology ; Cerebral Infarction/physiopathology* ; Cerebral Small Vessel Diseases/blood ; Cerebral Small Vessel Diseases/pathology ; Cerebral Small Vessel Diseases/physiopathology* ; Cerebrovascular Circulation ; Cross-Sectional Studies ; Down-Regulation* ; Fatty Acids, Omega-3/blood* ; Female ; Hospitals, University ; Humans ; Magnetic Resonance Imaging ; Male ; Microvessels/pathology ; Middle Aged ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology* ; Stroke, Lacunar/epidemiology ; Stroke, Lacunar/etiology ; White Matter/blood supply ; White Matter/pathology
Cerebral microbleeds ; Fatty acids composition ; Perivascular spaces ; Small vessel disease ; White matter changes ; n-3-polyunsaturated fatty acids
Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (± SD) was 2.0 ± 0.7 for EPA, 8.9 ± 1.5 for DHA, and 12.0 ± 2.1 for ∑ n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and ∑ n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and ∑ n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and ∑ n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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