Cited 34 times in
Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2018-03-26T17:11:55Z | - |
dc.date.available | 2018-03-26T17:11:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157328 | - |
dc.description.abstract | Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (± SD) was 2.0 ± 0.7 for EPA, 8.9 ± 1.5 for DHA, and 12.0 ± 2.1 for ∑ n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and ∑ n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and ∑ n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and ∑ n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Asymptomatic Diseases | - |
dc.subject.MESH | Brain Ischemia/epidemiology | - |
dc.subject.MESH | Brain Ischemia/etiology* | - |
dc.subject.MESH | Cerebral Infarction/blood | - |
dc.subject.MESH | Cerebral Infarction/pathology | - |
dc.subject.MESH | Cerebral Infarction/physiopathology* | - |
dc.subject.MESH | Cerebral Small Vessel Diseases/blood | - |
dc.subject.MESH | Cerebral Small Vessel Diseases/pathology | - |
dc.subject.MESH | Cerebral Small Vessel Diseases/physiopathology* | - |
dc.subject.MESH | Cerebrovascular Circulation | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Down-Regulation* | - |
dc.subject.MESH | Fatty Acids, Omega-3/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hospitals, University | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microvessels/pathology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stroke/epidemiology | - |
dc.subject.MESH | Stroke/etiology* | - |
dc.subject.MESH | Stroke, Lacunar/epidemiology | - |
dc.subject.MESH | Stroke, Lacunar/etiology | - |
dc.subject.MESH | White Matter/blood supply | - |
dc.subject.MESH | White Matter/pathology | - |
dc.title | Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Tae-Jin Song | - |
dc.contributor.googleauthor | Yoonkyung Chang | - |
dc.contributor.googleauthor | Min-Jeong Shin | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Yong-Jae Kim | - |
dc.identifier.doi | 10.1016/j.nutres.2015.04.008 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02401 | - |
dc.identifier.eissn | 1879-0739 | - |
dc.identifier.pmid | 25921638 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0271531715000743 | - |
dc.subject.keyword | Cerebral microbleeds | - |
dc.subject.keyword | Fatty acids composition | - |
dc.subject.keyword | Perivascular spaces | - |
dc.subject.keyword | Small vessel disease | - |
dc.subject.keyword | White matter changes | - |
dc.subject.keyword | n-3-polyunsaturated fatty acids | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 368 | - |
dc.citation.endPage | 374 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, Vol.35(5) : 368-374, 2015 | - |
dc.identifier.rimsid | 42361 | - |
dc.type.rims | ART | - |
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