0 100

Cited 18 times in

Level of secreted HMGB1 correlates with severity of inflammation in chronic rhinosinusitis

 Hyun Jin Min  ;  Su Jin Kim  ;  Tae Hoon Kim  ;  Hyo Jin Chung  ;  Joo-Heon Yoon  ;  Chang-Hoon Kim 
 LARYNGOSCOPE, Vol.125(7) : E225-E230, 2015 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Chronic Disease ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; HMGB1 Protein/metabolism* ; Humans ; Immunohistochemistry ; Inflammation/metabolism* ; Interleukin-1beta/metabolism ; Interleukin-8/metabolism ; Male ; Middle Aged ; Nasal Lavage Fluid ; Rhinitis/complications ; Rhinitis/metabolism* ; Severity of Illness Index ; Sinusitis/complications ; Sinusitis/metabolism* ; Tumor Necrosis Factor-alpha/metabolism ; Young Adult
HMGB1 ; Lund-Mackay score ; nasal lavage
OBJECTIVE: High mobility group box 1 (HMGB1) protein is a chromatin protein that functions as a proinflammatory cytokine when secreted in response to inflammatory stimuli. The purpose of this study was to determine the relationship between the HMGB1 level in nasal secretions and the severity of inflammation in chronic rhinosinusitis. STUDY DESIGN: This was a cross-sectional study. METHODS: Nasal secretions were obtained by irrigation of the affected sinonasal cavities with normal saline. Total 63 nasal lavage fluid samples were collected from 38 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Levels of HMGB1 and tumor necrosis factor alpha, interleukin (IL)-1β, and IL-8 were determined by enzyme-linked immunoassay. Severity of inflammation was assessed by the Lund-Mackay scoring system, which is based on preoperative computed tomography scans. Concurrent medical disorders, presence of nasal polyps, septal deviation, and allergic rhinitis were also investigated. RESULTS: The level of HMGB1 in nasal lavage fluid was positively correlated with the Lund-Mackay score. The score was the only factor associated with HMGB1 by univariate and multivariate analysis. Other cytokines, with the exception of IL-8, were not correlated with the Lund-Mackay score. CONCLUSION: Our results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund-Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Min, Hyun Jin(민현진)
Yoon, Joo Heon(윤주헌)
Chung, Hyo Jin(정효진)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.