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급성 칼슘통로차단제 중독에서 고용량 인슐린/정상혈당치료의 효과:체계적 고찰

Other Titles
 Effect of High Dose Insulin/Euglycemia Therapy for Acute Calcium Channel Blocker Intoxication: A Systematic Review 
 양진모  ;  고동률  ;  공태영  ;  주영선  ;  유제성  ;  정성필 
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.13(2) : 103-110, 2015 
Journal Title
Journal of the Korean Society of Clinical Toxicology(대한임상독성학회지)
Issue Date
Calcium channel blockers ; Poisoning ; Insulin
Purpose: The purpose of this study is to evaluate the effectiveness and the adverse events of high dose insulin/euglycemia therapy in acute calcium channel blocker (CCB) poisoning. Methods: We developed a systematic search strategy and applied it to 4 electronic reference databases. We searched medical journals as well as the bibliographies of relevant articles. All forms of literature relevant to human use of high dose insulin for acute CCB poisoning were included. The literature search was conducted by two investigators in August, 2015 with publication language restricted to English and Korean. Case reports were divided between CCB overdose alone and multi-drug overdose including CCB. The effect and adverse event of high dose insulin and clinical outcome of each case were analyzed. Results: Among 55 searched studies, 20 studies were included. A prospective study, a retrospective study, a systematic review study, and 17 case reports were identified. Case reports consisted of 11 CCB alone and 12 multidrug overdose cases including CCB. Although most cases described significant clinical improvements, one of them showed no beneficial effect. Several adverse events including hypoglycemia and hypokalemia were reported. No significant sequalae from adverse events was reported. Conclusion: Although there were many case reports demonstrating successful use of high dose insulin for CCB poisoning, the effect cannot be estimated due to a possibility of publication bias. Therefore, high dose insulin/euglycemia therapy might be considered adjunctive therapy in cases of CCB intoxication refractory for standard therapy.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Dong Ryul(고동률) ORCID logo https://orcid.org/0000-0002-3098-2784
Kong, Tae Young(공태영) ORCID logo https://orcid.org/0000-0002-4182-7245
Yang, Jinmo(양진모)
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
Joo, Young Seon(주영선)
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