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High Water Intake and Progression of Chronic Kidney Diseases

 Hoon Young Choi  ;  Hyeong Cheon Park  ;  Sung Kyu Ha 
 Electrolytes & Blood Pressure, Vol.13(2) : 46-51, 2015 
Journal Title
Electrolytes & Blood Pressure
Issue Date
Adolescent ; Adult ; Algorithms ; Coronary Angiography ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis* ; Female ; Humans ; Male ; Medical History Taking* ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/mortality ; Prognosis ; Proportional Hazards Models ; Reproducibility of Results ; Risk Assessment/methods* ; Risk Factors ; Tomography, X-Ray Computed ; Young Adult
Chronic kidney disease ; Dehydration ; Hydration ; Intake ; Progression ; Water
Impact of water intake on the courses of chronic kidney and urinary tract diseases, such as urolithiasis, urinary tract infections, chronic kidney diseases (CKD), autosomal dominant polycystic kidney diseases and bladder cancer, has recently been studied. It still remains controversial whether increased water intake slows the progression of CKD or not. However, high water intake suppresses plasma levels of arginine vasopressin (AVP), which is expected to be beneficial for the preservation of the kidney function. Previous studies suggest that water intake suppresses plasma levels of AVP, and high levels of AVP have been suggested to play deleterious roles in animal models of kidney disease. Moreover, recent epidemic of CKD of unknown origin, which was supposed to be related to the insufficient water intake and chronic volume depletion, has been reported in Central America, further suggesting that the suppression of AVP by sustained water intake might be beneficial in this CKD population. Indeed, the data from recent studies were consistent with the view that high water intake is associated with slower progression of CKD. However, contradictory findings also exist. The intriguing effects of increased urine volume in preserving the glomerular filtration rate in human patients with CKD require more large and well-designed randomized prospective clinical trials.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Ha, Sung Kyu(하성규)
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