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Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines

 Jong Gyun Ahn  ;  Seong Yeol Choi  ;  Dong Soo Kim  ;  Ki Hwan Kim 
 INFECTIOUS DISEASES, Vol.47(6) : 385-392, 2015 
Journal Title
Issue Date
Child, Preschool ; Female ; Heptavalent Pneumococcal Conjugate Vaccine/administration & dosage ; Heptavalent Pneumococcal Conjugate Vaccine/immunology ; Humans ; Infant ; Male ; Multiplex Polymerase Chain Reaction ; Nasopharynx/microbiology* ; Pneumococcal Vaccines/administration & dosage* ; Pneumococcal Vaccines/immunology ; Republic of Korea ; Respiratory Tract Infections/drug therapy* ; Respiratory Tract Infections/microbiology ; Serogroup ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/growth & development* ; Streptococcus pneumoniae/isolation & purification ; Time Factors
Streptococcus pneumoniae ; nasopharyngeal colonization ; pneumococcal conjugate vaccine ; serotype
BACKGROUND: The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent PCV (PCV7) in May 2010 in Korea. We investigated the dynamics of pneumococcal nasopharyngeal (NP) colonization in children with a respiratory illness before and after use of PHiD-CV and PCV13. METHODS: From March 2009 to December 2012 NP secretions were obtained from 2176 children aged < 5 years with respiratory diseases. We used the multiplex polymerase chain reaction (PCR) technique to determine pneumococcal serotypes. RESULTS: Among the samples, 468 (21.5%) specimens were positive by multiplex PCR. The overall pneumococcal colonization rate remained stable during the 2009-2012 periods. The serotypes present in PCV7 and serotype 19A decreased in frequency from 36.8% and 26.4% in 2009 to 10.1% and 11.4% in 2012, respectively (χ(2) for trend, P < 0.001 and P = 0.007, respectively). The frequency of non-PCV13 serotypes increased from 36.8% in 2009 to 78.5% in 2012 (χ(2) for trend, P < 0.001). There was no significant difference in carriage rates of each serotype between groups of children that received PCV7, PHiD-CV, or PCV13. CONCLUSIONS: Compared with the period of PCV7 vaccination, overall carriage rate was not affected by the introduction of new PCVs. However, serotype distribution now consists mostly of non-vaccine serotypes. PCVs affect mucosal immunity against Streptococcus pneumoniae (SP) in NP carriage; but, global SP colonization seems to be maintained by replacement.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
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