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Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines
DC Field | Value | Language |
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dc.contributor.author | 김기환 | - |
dc.contributor.author | 김동수 | - |
dc.contributor.author | 안종균 | - |
dc.date.accessioned | 2018-03-26T17:04:38Z | - |
dc.date.available | 2018-03-26T17:04:38Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2374-4235 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157149 | - |
dc.description.abstract | BACKGROUND: The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent PCV (PCV7) in May 2010 in Korea. We investigated the dynamics of pneumococcal nasopharyngeal (NP) colonization in children with a respiratory illness before and after use of PHiD-CV and PCV13. METHODS: From March 2009 to December 2012 NP secretions were obtained from 2176 children aged < 5 years with respiratory diseases. We used the multiplex polymerase chain reaction (PCR) technique to determine pneumococcal serotypes. RESULTS: Among the samples, 468 (21.5%) specimens were positive by multiplex PCR. The overall pneumococcal colonization rate remained stable during the 2009-2012 periods. The serotypes present in PCV7 and serotype 19A decreased in frequency from 36.8% and 26.4% in 2009 to 10.1% and 11.4% in 2012, respectively (χ(2) for trend, P < 0.001 and P = 0.007, respectively). The frequency of non-PCV13 serotypes increased from 36.8% in 2009 to 78.5% in 2012 (χ(2) for trend, P < 0.001). There was no significant difference in carriage rates of each serotype between groups of children that received PCV7, PHiD-CV, or PCV13. CONCLUSIONS: Compared with the period of PCV7 vaccination, overall carriage rate was not affected by the introduction of new PCVs. However, serotype distribution now consists mostly of non-vaccine serotypes. PCVs affect mucosal immunity against Streptococcus pneumoniae (SP) in NP carriage; but, global SP colonization seems to be maintained by replacement. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heptavalent Pneumococcal Conjugate Vaccine/administration & dosage | - |
dc.subject.MESH | Heptavalent Pneumococcal Conjugate Vaccine/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multiplex Polymerase Chain Reaction | - |
dc.subject.MESH | Nasopharynx/microbiology* | - |
dc.subject.MESH | Pneumococcal Vaccines/administration & dosage* | - |
dc.subject.MESH | Pneumococcal Vaccines/immunology | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Respiratory Tract Infections/drug therapy* | - |
dc.subject.MESH | Respiratory Tract Infections/microbiology | - |
dc.subject.MESH | Serogroup | - |
dc.subject.MESH | Streptococcus pneumoniae/classification | - |
dc.subject.MESH | Streptococcus pneumoniae/genetics | - |
dc.subject.MESH | Streptococcus pneumoniae/growth & development* | - |
dc.subject.MESH | Streptococcus pneumoniae/isolation & purification | - |
dc.subject.MESH | Time Factors | - |
dc.title | Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Jong Gyun Ahn | - |
dc.contributor.googleauthor | Seong Yeol Choi | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Ki Hwan Kim | - |
dc.identifier.doi | 10.3109/00365548.2014.1001997 | - |
dc.contributor.localId | A00344 | - |
dc.contributor.localId | A00405 | - |
dc.contributor.localId | A02261 | - |
dc.relation.journalcode | J02913 | - |
dc.identifier.eissn | 2374-4243 | - |
dc.identifier.pmid | 25712791 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.3109/00365548.2014.1001997 | - |
dc.subject.keyword | Streptococcus pneumoniae | - |
dc.subject.keyword | nasopharyngeal colonization | - |
dc.subject.keyword | pneumococcal conjugate vaccine | - |
dc.subject.keyword | serotype | - |
dc.contributor.alternativeName | Kim, Ki Hwan | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Ahn, Jong Gyun | - |
dc.contributor.affiliatedAuthor | Kim, Ki Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | Ahn, Jong Gyun | - |
dc.citation.volume | 47 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 385 | - |
dc.citation.endPage | 392 | - |
dc.identifier.bibliographicCitation | INFECTIOUS DISEASES, Vol.47(6) : 385-392, 2015 | - |
dc.identifier.rimsid | 41712 | - |
dc.type.rims | ART | - |
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