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폴리크레줄렌을 배합한 치약의 항치태 및 항치은염 효과에 관한 임상연구

Other Titles
 Efficacy of dentifrices containing policresulen in controlling dental plaque and gingivitis formation 
 김보라  ;  고혜연  ;  한선영  ;  김희은  ;  정은하  ;  유아람  ;  하원호  ;  권호근  ;  김백일 
 Journal of Korean Academy of Oral Health (대한구강보건학회지), Vol.39(4) : 267-272, 2015 
Journal Title
Journal of Korean Academy of Oral Health(대한구강보건학회지)
Issue Date
Clinical trial ; Dental plaque index ; Dentifrices ; Gingival hemorrhage ; Gingivitis
Objectives : This clinical study aimed to investigate if dentifrices containing policresulen would help to control dental plaque and gingivitis.

Methods : Seventy-eight eligible adults participated in this double-blind and randomized clinical study after an initial oral examination, calculus removal, and tooth prophylaxis. Two weeks after the procedure, the participants were assigned to three groups using the following dentifrices: (1) a dentifrice containing 0.22% NaF (control group); (2) a dentifrice containing 0.22% NaF and 100 ppm policresulen (policresulen group); and (3) a dentifrice containing 0.22% NaF, 100 ppm policresulen, and 1.00% bamboo salt (policresulen/bamboo group). The participants used only the provided dentifrice (for 1 min, twice a day, over 8 weeks) when brushing their teeth and followed their normal brushing habits. Dental plaque accumulation and gingivitis measurements were conducted using the Turesky modification of the Quigley-Hein plaque index (PI), the Löe and Silness gingival index (GI), and the percent bleeding on probing (%BOP) to obtain baseline data and 4- and 8-week data after grouping.

Results : A total of 73 participants aged 35.92±11.46 years (mean±SD) completed the study. The results after 8 weeks demonstrated statistically significant group-by-time interactions for PI, GI, and %BOP (P<0.001). The PI observed in the control groups increased over time up to 6%, while that observed in the dentifrice groups containing policresulen decreased by 5% (P<0.001). For GI and %BOP, the control group exhibited significantly higher values after 8 weeks, while the policresulen and the policresulen/bamboo groups revealed similar index values as the baseline after 4 and 8 weeks. The changes in all indices were significantly different between the control and the two experimental groups. There were no significant differences in the results obtained from the policresulen/bamboo group and the results obtained from the policresulen group.

Conclusions : Use of dentifrices containing policresulen over 8 weeks demonstrated anti-plaque and anti-gingivitis efficacy compared to a control dentifrice.
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2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho Keun(권호근)
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Kim, Bo Ra(김보라)
Jung, Eun Ha(정은하)
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