Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Fredrick R. Schumacher; Stephanie L. Schmit; Shuo Jiao; Christopher K. Edlund; Hansong Wang; Ben Zhang; Li Hsu; Shu-Chen Huang; Christopher P. Fischer; John F. Harju; Gregory E. Idos; Stephen B. Gruber; Ulrike Peters; Flavio Lejbkowicz; Frank J. Manion; Kevin McDonnell; Caroline E. McNeil; Marilena Melas; Hedy S. Rennert; WeiShi; Duncan C. Thomas; David J. Van Den Berg; Carolyn M. Hutter; Aaron K. Aragaki; Katja Butterbach; Bette J. Caan; Christopher S. Carlson; Stephen J. Chanock; Keith R. Curtis; Charles S. Fuchs; Manish Gala; Edward L. Giovannucci; Stephanie M. Gogarten; Richard B. Hayes; Brian Henderson; David J. Hunter; Rebecca D. Jackson; Laurence N. Kolonel; Charles Kooperberg; Sébastien Küry; Andrea LaCroix; Cathy C. Laurie; Cecelia A. Laurie; Mathieu Lemire; David Levine; Jing Ma; Karen W. Makar; Conghui Qu; Darin Taverna; Cornelia M. Ulrich; Kana Wu; Suminori Kono; Dee W. West; Sonja I. Berndt; Stéphane Bezieau; Hermann Brenner; Peter T. Campbell; Andrew T. Chan; Jenny Chang-Claude; Gerhard A. Coetzee; David V. Conti; David Duggan; Jane C. Figueiredo; Barbara K. Fortini; Steven J. Gallinger; W. James Gauderman; Graham Giles; Roger Green; Robert Haile; Tabitha A. Harrison; Michael Hoffmeister; John L. Hopper; Thomas J. Hudson; Eric Jacobs; Motoki Iwasaki; Sun Ha Jee; Mark Jenkins; Wei-Hua Jia; Amit Joshi; Li Li; Noralene M. Lindor; Keitaro Matsuo; Victor Moreno; Bhramar Mukherjee; Polly A. Newcomb; John D. Potter; Leon Raskin; Gad Rennert; Stephanie Rosse; Gianluca Severi; Robert E. Schoen; Daniela Seminara; Xiao-Ou Shu; Martha L. Slattery; Shoichiro Tsugane; Emily White; Yong-Bing Xiang; Brent W. Zanke; Wei Zheng; Loic Le Marchand; Graham Casey

doi:10.1038/ncomms8138

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Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Authors: Fredrick R. Schumacher ; Stephanie L. Schmit ; Shuo Jiao ; Christopher K. Edlund ; Hansong Wang ; Ben Zhang ; Li Hsu ; Shu-Chen Huang ; Christopher P. Fischer ; John F. Harju ; Gregory E. Idos ; Stephen B. Gruber ; Ulrike Peters ; Flavio Lejbkowicz ; Frank J. Manion ; Kevin McDonnell ; Caroline E. McNeil ; Marilena Melas ; Hedy S. Rennert ; WeiShi ; Duncan C. Thomas ; David J. Van Den Berg ; Carolyn M. Hutter ; Aaron K. Aragaki ; Katja Butterbach ; Bette J. Caan ; Christopher S. Carlson ; Stephen J. Chanock ; Keith R. Curtis ; Charles S. Fuchs ; Manish Gala ; Edward L. Giovannucci ; Stephanie M. Gogarten ; Richard B. Hayes ; Brian Henderson ; David J. Hunter ; Rebecca D. Jackson ; Laurence N. Kolonel ; Charles Kooperberg ; Sébastien Küry ; Andrea LaCroix ; Cathy C. Laurie ; Cecelia A. Laurie ; Mathieu Lemire ; David Levine ; Jing Ma ; Karen W. Makar ; Conghui Qu ; Darin Taverna ; Cornelia M. Ulrich ; Kana Wu ; Suminori Kono ; Dee W. West ; Sonja I. Berndt ; Stéphane Bezieau ; Hermann Brenner ; Peter T. Campbell ; Andrew T. Chan ; Jenny Chang-Claude ; Gerhard A. Coetzee ; David V. Conti ; David Duggan ; Jane C. Figueiredo ; Barbara K. Fortini ; Steven J. Gallinger ; W. James Gauderman ; Graham Giles ; Roger Green ; Robert Haile ; Tabitha A. Harrison ; Michael Hoffmeister ; John L. Hopper ; Thomas J. Hudson ; Eric Jacobs ; Motoki Iwasaki ; Sun Ha Jee ; Mark Jenkins ; Wei-Hua Jia ; Amit Joshi ; Li Li ; Noralene M. Lindor ; Keitaro Matsuo ; Victor Moreno ; Bhramar Mukherjee ; Polly A. Newcomb ; John D. Potter ; Leon Raskin ; Gad Rennert ; Stephanie Rosse ; Gianluca Severi ; Robert E. Schoen ; Daniela Seminara ; Xiao-Ou Shu ; Martha L. Slattery ; Shoichiro Tsugane ; Emily White ; Yong-Bing Xiang ; Brent W. Zanke ; Wei Zheng ; Loic Le Marchand ; Graham Casey

Citation: NATURE COMMUNICATIONS, Vol.6 : 7138, 2015

Journal Title: NATURE COMMUNICATIONS

Issue Date: 2015

MeSH: Case-Control Studies ; Colorectal Neoplasms/genetics* ; Genetic Predisposition to Disease* ; Genome-Wide Association Study* ; Humans ; Odds Ratio ; Polymorphism, Single Nucleotide

Abstract: Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.