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Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Authors
 Fredrick R. Schumacher  ;  Stephanie L. Schmit  ;  Shuo Jiao  ;  Christopher K. Edlund  ;  Hansong Wang  ;  Ben Zhang  ;  Li Hsu  ;  Shu-Chen Huang  ;  Christopher P. Fischer  ;  John F. Harju  ;  Gregory E. Idos  ;  Stephen B. Gruber  ;  Ulrike Peters  ;  Flavio Lejbkowicz  ;  Frank J. Manion  ;  Kevin McDonnell  ;  Caroline E. McNeil  ;  Marilena Melas  ;  Hedy S. Rennert  ;  WeiShi  ;  Duncan C. Thomas  ;  David J. Van Den Berg  ;  Carolyn M. Hutter  ;  Aaron K. Aragaki  ;  Katja Butterbach  ;  Bette J. Caan  ;  Christopher S. Carlson  ;  Stephen J. Chanock  ;  Keith R. Curtis  ;  Charles S. Fuchs  ;  Manish Gala  ;  Edward L. Giovannucci  ;  Stephanie M. Gogarten  ;  Richard B. Hayes  ;  Brian Henderson  ;  David J. Hunter  ;  Rebecca D. Jackson  ;  Laurence N. Kolonel  ;  Charles Kooperberg  ;  Sébastien Küry  ;  Andrea LaCroix  ;  Cathy C. Laurie  ;  Cecelia A. Laurie  ;  Mathieu Lemire  ;  David Levine  ;  Jing Ma  ;  Karen W. Makar  ;  Conghui Qu  ;  Darin Taverna  ;  Cornelia M. Ulrich  ;  Kana Wu  ;  Suminori Kono  ;  Dee W. West  ;  Sonja I. Berndt  ;  Stéphane Bezieau  ;  Hermann Brenner  ;  Peter T. Campbell  ;  Andrew T. Chan  ;  Jenny Chang-Claude  ;  Gerhard A. Coetzee  ;  David V. Conti  ;  David Duggan  ;  Jane C. Figueiredo  ;  Barbara K. Fortini  ;  Steven J. Gallinger  ;  W. James Gauderman  ;  Graham Giles  ;  Roger Green  ;  Robert Haile  ;  Tabitha A. Harrison  ;  Michael Hoffmeister  ;  John L. Hopper  ;  Thomas J. Hudson  ;  Eric Jacobs  ;  Motoki Iwasaki  ;  Sun Ha Jee  ;  Mark Jenkins  ;  Wei-Hua Jia  ;  Amit Joshi  ;  Li Li  ;  Noralene M. Lindor  ;  Keitaro Matsuo  ;  Victor Moreno  ;  Bhramar Mukherjee  ;  Polly A. Newcomb  ;  John D. Potter  ;  Leon Raskin  ;  Gad Rennert  ;  Stephanie Rosse  ;  Gianluca Severi  ;  Robert E. Schoen  ;  Daniela Seminara  ;  Xiao-Ou Shu  ;  Martha L. Slattery  ;  Shoichiro Tsugane  ;  Emily White  ;  Yong-Bing Xiang  ;  Brent W. Zanke  ;  Wei Zheng  ;  Loic Le Marchand  ;  Graham Casey 
Citation
 NATURE COMMUNICATIONS, Vol.6 : 7138, 2015 
Journal Title
 NATURE COMMUNICATIONS 
Issue Date
2015
MeSH
Case-Control Studies ; Colorectal Neoplasms/genetics* ; Genetic Predisposition to Disease* ; Genome-Wide Association Study* ; Humans ; Odds Ratio ; Polymorphism, Single Nucleotide
Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
Files in This Item:
T201505525.pdf Download
DOI
10.1038/ncomms8138
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157120
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