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Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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dc.contributor.author지선하-
dc.date.accessioned2018-03-26T17:03:19Z-
dc.date.available2018-03-26T17:03:19Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157120-
dc.description.abstractGenetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHGenetic Predisposition to Disease*-
dc.subject.MESHGenome-Wide Association Study*-
dc.subject.MESHHumans-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.titleGenome-wide association study of colorectal cancer identifies six new susceptibility loci-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health-
dc.contributor.departmentGraduate School of Public Health-
dc.contributor.googleauthorFredrick R. Schumacher-
dc.contributor.googleauthorStephanie L. Schmit-
dc.contributor.googleauthorShuo Jiao-
dc.contributor.googleauthorChristopher K. Edlund-
dc.contributor.googleauthorHansong Wang-
dc.contributor.googleauthorBen Zhang-
dc.contributor.googleauthorLi Hsu-
dc.contributor.googleauthorShu-Chen Huang-
dc.contributor.googleauthorChristopher P. Fischer-
dc.contributor.googleauthorJohn F. Harju-
dc.contributor.googleauthorGregory E. Idos-
dc.contributor.googleauthorStephen B. Gruber-
dc.contributor.googleauthorUlrike Peters-
dc.contributor.googleauthorFlavio Lejbkowicz-
dc.contributor.googleauthorFrank J. Manion-
dc.contributor.googleauthorKevin McDonnell-
dc.contributor.googleauthorCaroline E. McNeil-
dc.contributor.googleauthorMarilena Melas-
dc.contributor.googleauthorHedy S. Rennert-
dc.contributor.googleauthorWeiShi-
dc.contributor.googleauthorDuncan C. Thomas-
dc.contributor.googleauthorDavid J. Van Den Berg-
dc.contributor.googleauthorCarolyn M. Hutter-
dc.contributor.googleauthorAaron K. Aragaki-
dc.contributor.googleauthorKatja Butterbach-
dc.contributor.googleauthorBette J. Caan-
dc.contributor.googleauthorChristopher S. Carlson-
dc.contributor.googleauthorStephen J. Chanock-
dc.contributor.googleauthorKeith R. Curtis-
dc.contributor.googleauthorCharles S. Fuchs-
dc.contributor.googleauthorManish Gala-
dc.contributor.googleauthorEdward L. Giovannucci-
dc.contributor.googleauthorStephanie M. Gogarten-
dc.contributor.googleauthorRichard B. Hayes-
dc.contributor.googleauthorBrian Henderson-
dc.contributor.googleauthorDavid J. Hunter-
dc.contributor.googleauthorRebecca D. Jackson-
dc.contributor.googleauthorLaurence N. Kolonel-
dc.contributor.googleauthorCharles Kooperberg-
dc.contributor.googleauthorSébastien Küry-
dc.contributor.googleauthorAndrea LaCroix-
dc.contributor.googleauthorCathy C. Laurie-
dc.contributor.googleauthorCecelia A. Laurie-
dc.contributor.googleauthorMathieu Lemire-
dc.contributor.googleauthorDavid Levine-
dc.contributor.googleauthorJing Ma-
dc.contributor.googleauthorKaren W. Makar-
dc.contributor.googleauthorConghui Qu-
dc.contributor.googleauthorDarin Taverna-
dc.contributor.googleauthorCornelia M. Ulrich-
dc.contributor.googleauthorKana Wu-
dc.contributor.googleauthorSuminori Kono-
dc.contributor.googleauthorDee W. West-
dc.contributor.googleauthorSonja I. Berndt-
dc.contributor.googleauthorStéphane Bezieau-
dc.contributor.googleauthorHermann Brenner-
dc.contributor.googleauthorPeter T. Campbell-
dc.contributor.googleauthorAndrew T. Chan-
dc.contributor.googleauthorJenny Chang-Claude-
dc.contributor.googleauthorGerhard A. Coetzee-
dc.contributor.googleauthorDavid V. Conti-
dc.contributor.googleauthorDavid Duggan-
dc.contributor.googleauthorJane C. Figueiredo-
dc.contributor.googleauthorBarbara K. Fortini-
dc.contributor.googleauthorSteven J. Gallinger-
dc.contributor.googleauthorW. James Gauderman-
dc.contributor.googleauthorGraham Giles-
dc.contributor.googleauthorRoger Green-
dc.contributor.googleauthorRobert Haile-
dc.contributor.googleauthorTabitha A. Harrison-
dc.contributor.googleauthorMichael Hoffmeister-
dc.contributor.googleauthorJohn L. Hopper-
dc.contributor.googleauthorThomas J. Hudson-
dc.contributor.googleauthorEric Jacobs-
dc.contributor.googleauthorMotoki Iwasaki-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorMark Jenkins-
dc.contributor.googleauthorWei-Hua Jia-
dc.contributor.googleauthorAmit Joshi-
dc.contributor.googleauthorLi Li-
dc.contributor.googleauthorNoralene M. Lindor-
dc.contributor.googleauthorKeitaro Matsuo-
dc.contributor.googleauthorVictor Moreno-
dc.contributor.googleauthorBhramar Mukherjee-
dc.contributor.googleauthorPolly A. Newcomb-
dc.contributor.googleauthorJohn D. Potter-
dc.contributor.googleauthorLeon Raskin-
dc.contributor.googleauthorGad Rennert-
dc.contributor.googleauthorStephanie Rosse-
dc.contributor.googleauthorGianluca Severi-
dc.contributor.googleauthorRobert E. Schoen-
dc.contributor.googleauthorDaniela Seminara-
dc.contributor.googleauthorXiao-Ou Shu-
dc.contributor.googleauthorMartha L. Slattery-
dc.contributor.googleauthorShoichiro Tsugane-
dc.contributor.googleauthorEmily White-
dc.contributor.googleauthorYong-Bing Xiang-
dc.contributor.googleauthorBrent W. Zanke-
dc.contributor.googleauthorWei Zheng-
dc.contributor.googleauthorLoic Le Marchand-
dc.contributor.googleauthorGraham Casey-
dc.identifier.doi10.1038/ncomms8138-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid26151821-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume6-
dc.citation.startPage7138-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.6 : 7138, 2015-
dc.identifier.rimsid41683-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
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