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Helicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia

Authors
 Seung Hwan Shin  ;  Da Hyun Jung  ;  Jie-Hyun Kim  ;  Hyun Soo Chung  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
Citation
 PLOS ONE, Vol.10(11) : e0143257, 2015 
Journal Title
 PLOS ONE 
Issue Date
2015
MeSH
Aged ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use* ; Carcinoma in Situ/drug therapy* ; Carcinoma in Situ/microbiology ; Carcinoma in Situ/pathology ; Carcinoma in Situ/surgery ; Clarithromycin/therapeutic use ; Female ; Gastric Mucosa/drug effects ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Gastric Mucosa/surgery ; Gastroscopy ; Helicobacter Infections/drug therapy* ; Helicobacter Infections/microbiology ; Helicobacter Infections/pathology ; Helicobacter Infections/surgery ; Helicobacter pylori/drug effects ; Helicobacter pylori/pathogenicity ; Helicobacter pylori/physiology ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/microbiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control* ; Neoplasms, Second Primary/microbiology ; Neoplasms, Second Primary/pathology ; Neoplasms, Second Primary/prevention & control* ; Proton Pump Inhibitors/therapeutic use ; Retrospective Studies ; Stomach/drug effects ; Stomach/microbiology ; Stomach/pathology ; Stomach/surgery ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
Abstract
PURPOSE: There is insufficient data about the role of eradication of H. pylori after endoscopic resection (ER) for gastric dysplasia. The aim was to investigate the benefit of H. pylori eradication after ER in patients with gastric dysplasia to prevent metachronous gastric neoplasms. MATERIALS AND METHODS: We retrospectively reviewed 1872 patients who underwent ER of gastric dysplasia. We excluded patients with a follow-up period of <2 years or who had not undergone tests for active H. pylori infection. A total of 282 patients were enrolled. The patients were categorized into those without active H. pylori infection (H. pylori-negative group, n = 124), those who successfully underwent H. pylori eradication (eradicated group, n = 122), and those who failed or did not undergo H. pylori eradication (persistent group, n = 36). RESULTS: Metachronous recurrence was diagnosed in 36 patients, including 19 in the H. pylori-negative group, 10 in the eradicated group, and 7 in the persistent group. The cumulative incidence of metachronous recurrence was significantly lower in the H. pylori-eradicated group in comparison with either of the H. pylori-persistent (non-eradicated or failed) groups (p = 0.039). Similarly, the incidence of metachronous recurrence was significantly lower in the H. pylori-eradicated group compared with the H. pylori-negative group (p = 0.041). CONCLUSION: Successful H. pylori eradication may reduce the development of metachronous gastric neoplasms after ER in patients with gastric dysplasia.
Files in This Item:
T201505327.pdf Download
DOI
10.1371/journal.pone.0143257
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Shin, Seung Hwan(신승환)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Jung, Da Hyun(정다현)
Chung, Hyun Soo(정현수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157085
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