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Helicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia

DC Field Value Language
dc.contributor.author김지현-
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author신승환-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author정다현-
dc.contributor.author정현수-
dc.date.accessioned2018-03-26T17:01:28Z-
dc.date.available2018-03-26T17:01:28Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157085-
dc.description.abstractPURPOSE: There is insufficient data about the role of eradication of H. pylori after endoscopic resection (ER) for gastric dysplasia. The aim was to investigate the benefit of H. pylori eradication after ER in patients with gastric dysplasia to prevent metachronous gastric neoplasms. MATERIALS AND METHODS: We retrospectively reviewed 1872 patients who underwent ER of gastric dysplasia. We excluded patients with a follow-up period of <2 years or who had not undergone tests for active H. pylori infection. A total of 282 patients were enrolled. The patients were categorized into those without active H. pylori infection (H. pylori-negative group, n = 124), those who successfully underwent H. pylori eradication (eradicated group, n = 122), and those who failed or did not undergo H. pylori eradication (persistent group, n = 36). RESULTS: Metachronous recurrence was diagnosed in 36 patients, including 19 in the H. pylori-negative group, 10 in the eradicated group, and 7 in the persistent group. The cumulative incidence of metachronous recurrence was significantly lower in the H. pylori-eradicated group in comparison with either of the H. pylori-persistent (non-eradicated or failed) groups (p = 0.039). Similarly, the incidence of metachronous recurrence was significantly lower in the H. pylori-eradicated group compared with the H. pylori-negative group (p = 0.041). CONCLUSION: Successful H. pylori eradication may reduce the development of metachronous gastric neoplasms after ER in patients with gastric dysplasia.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAmoxicillin/therapeutic use-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHCarcinoma in Situ/drug therapy*-
dc.subject.MESHCarcinoma in Situ/microbiology-
dc.subject.MESHCarcinoma in Situ/pathology-
dc.subject.MESHCarcinoma in Situ/surgery-
dc.subject.MESHClarithromycin/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHGastric Mucosa/drug effects-
dc.subject.MESHGastric Mucosa/microbiology-
dc.subject.MESHGastric Mucosa/pathology-
dc.subject.MESHGastric Mucosa/surgery-
dc.subject.MESHGastroscopy-
dc.subject.MESHHelicobacter Infections/drug therapy*-
dc.subject.MESHHelicobacter Infections/microbiology-
dc.subject.MESHHelicobacter Infections/pathology-
dc.subject.MESHHelicobacter Infections/surgery-
dc.subject.MESHHelicobacter pylori/drug effects-
dc.subject.MESHHelicobacter pylori/pathogenicity-
dc.subject.MESHHelicobacter pylori/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/microbiology-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/prevention & control*-
dc.subject.MESHNeoplasms, Second Primary/microbiology-
dc.subject.MESHNeoplasms, Second Primary/pathology-
dc.subject.MESHNeoplasms, Second Primary/prevention & control*-
dc.subject.MESHProton Pump Inhibitors/therapeutic use-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach/drug effects-
dc.subject.MESHStomach/microbiology-
dc.subject.MESHStomach/pathology-
dc.subject.MESHStomach/surgery-
dc.subject.MESHStomach Neoplasms/drug therapy*-
dc.subject.MESHStomach Neoplasms/microbiology-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHStomach Neoplasms/surgery-
dc.titleHelicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSeung Hwan Shin-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorHyun Soo Chung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.identifier.doi10.1371/journal.pone.0143257-
dc.contributor.localIdA00996-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02122-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03591-
dc.contributor.localIdA03765-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid26580072-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameShin, Seung Hwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameJung, Da Hyun-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorShin, Seung Hwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorJung, Da Hyun-
dc.contributor.affiliatedAuthorChung, Hyun Soo-
dc.citation.volume10-
dc.citation.number11-
dc.citation.startPagee0143257-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(11) : e0143257, 2015-
dc.identifier.rimsid41649-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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