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Association Between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes With Choroidal Melanoma

 Ji Hwan Lee  ;  Sung Chul Lee  ;  Arthur Cho  ;  Ki Chang Keum  ;  Yang-Gun Suh  ;  Christopher Seungkyu Lee 
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.160(6) : 1111-1115, 2015 
Journal Title
Issue Date
Brachytherapy ; Choroid/diagnostic imaging ; Choroid/metabolism ; Choroid/pathology* ; Choroid Neoplasms/diagnostic imaging* ; Choroid Neoplasms/pathology ; Choroid Neoplasms/radiotherapy ; Disease Progression ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Follow-Up Studies ; Humans ; Male ; Melanoma/diagnostic imaging* ; Melanoma/pathology ; Melanoma/radiotherapy ; Middle Aged ; Positron-Emission Tomography/methods* ; Radiopharmaceuticals/pharmacokinetics ; Retrospective Studies ; Tomography, Optical Coherence
PURPOSE: To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma.

DESIGN: Retrospective, interventional case series.

METHODS: The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment.

RESULTS: Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P = .003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P = .019). In tumor eyes, mean choroidal thickness significantly decreased from pretreatment values to 253.56 ± 61.27 μm 6 months after treatment (P = .018).

CONCLUSION: Eyes with choroidal melanoma had thicker choroids than unaffected fellow eyes. Increased choroidal thickness was more prominent in metabolically active tumors. Choroidal thickness significantly decreased in tumor eyes 6 months after treatment.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Suh, Yang Gun(서양권)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Ji Hwan(이지환) ORCID logo https://orcid.org/0000-0003-1759-8195
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
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